The freshman Peppers did not practice on Sunday and was planning to receive treatment on his ankle Monday morning.
After Michigan's 52-14 victory over Appalachian State on Saturday, Peppers tweeted that he would play in the Wolverines' next game.
"He's been in there all morning getting treatment, we haven't started school yet (so he has time)," head coach Brady Hoke said. "We decided, I made a decision at halftime, so they could start treating it right then. (We didn't bring him out) in the second half, he'd have (just) been in a boot on the sideline.
Peppers was ranked the third-best player in the country by Rivals.com for the class of 2014. He was listed as the top cornerback in the nation.
- Sarah Barshop