Alex Hamilton had 13 points, Raheem Appleby added 11 points and Kenneth Smith had 10 assists for Louisiana Tech (7-1). The Bulldogs scored 10 straight early in the second half and stretched their lead to 18 with 4:45 to go.
Jackson State (1-7) closed the first half on a 12-3 run after Kyser's dunk midway through the half gave Louisiana Tech a 24-15 lead. Kaven Bernard's 3-pointer with 33 seconds left cut the Bulldogs' lead to 27-26 before halftime.
The Tigers outrebounded Louisiana Tech 49-32, but couldn't overcome 22 turnovers.
Bernard had 15 points and Derell Taylor had 11 rebounds to lead Jackson State.