Raheem Appleby chipped in 18 points, Kenneth Smith added 10 assists with seven rebounds, and Michale Kyser had nine points and six blocks for the Bulldogs (14-4, 5-0 Conference USA). Hamilton was 5 of 9 from the floor, 20 of 23 at the line and grabbed six boards as Louisiana Tech won its sixth straight.
JaQuel Richmond led Middle Tennessee (10-8, 3-2) with 14 points, Reggie Upshaw Jr. contributed 12 and Perrin Buford had nine with 11 rebounds.
The Bulldogs made three layups and Hamilton sank four free throws during a 10-0 surge that made it 57-44 with 9:59 remaining. Middle Tennessee pulled within four late, but Hamilton hit a layup and 3 of 4 free throws in the final two minutes to seal it.