It will be the first game in the series broadcasted on ESPN that Vitale won't work since he joined the network in 1979.
Vitale declined comment to Jones, but last week he tweeted about the end of the streak.
Vitale had called the last few games in the series with play-by-play commentator Dan Shulman and former Duke player Jay Bilas, but the pair will call the game without him on Wednesday.
Duke is 22-3 on the season and 9-3 in ACC play, while North Carolina is 18-7 overall and 8-4 in conference play. The Blue Devils beat the Tar Heels in the last meeting between the teams in March 2014.
Duke hosts North Carolina on Wednesday at 9 p.m. ET.
- Paul Palladino