Breida had touchdown runs of 83 and 66 yards for the Eagles (3-1, 1-0). Kevin Ellison threw for 105 yards and rushed for 134 yards and two touchdowns. Alex Hanks kicked three field goals.
Breida's first touchdown run and a trio of field goals by Hanks lifted Georgia Southern to a 16-13 halftime lead.
The Eagles scored four more touchdowns in the second half including Breida's second just three plays into the third quarter, one by Wesley Fields on the team's next possession and Ellison's two touchdowns in the fourth quarter to cap the victory for Georgia Southern.
Matt Linehan completed 20 of 35 passes for 284 yards and two touchdowns for the Vandals (1-3, 0-1).
AP college football website: http://collegefootball.ap.org