Geoffrey Groselle added 17 points on 6-for-9 shooting with nine rebounds and three blocked shots for the Blue Jays (5-1). Groselle was largely unchallenged underneath, adding a two-handed dunk after halftime, and a one-handed put-back dunk in the first half. Creighton outrebounded Western Illinois 47-29 and shot 51 percent from the floor (35 of 69).
The Leathernecks (5-1) had come into the game tied for the program's best start in Division I (5-0, 1986-87). But Creighton was red-hot, leading 44-31 by halftime and opening the second half on a 14-7 run.
Creighton led by as many as 32 points, 95-63.
James Milliken scored 12 points - all in the first half - for Creighton.
Western Illinois was led by Garret Covington's 14 points and 13 from Jalen Chapman.