Creighton (9-4), which beat North Texas 105-82 last Monday, scored 100 or more points in consecutive games for the first time since the 1965-66 season.
Groselle made all eight of his field goal attempts and Zierden hit 6 of 7 shots as the Bluejays made 61 percent (37 of 61) from the field. They shot 69 percent in the first half.
Cole Huff scored 14, Malik Albert 12, and Khyri Thomas, Zach Hanson and Maurice Watson Jr. had 10 points each for Creighton.
Trevon Seymore had 22 points for Coppin State (2-12).