Wide Receiver Start ‘Em, Sit ‘Em For Fantasy Football Week 6

Michael Fabiano | Oct 12, 2025

Sit Jameson Williams in fantasy football Week 6. / Cooper Neill/Getty Images

Start ‘Em, Sit 'Em is the ultimate look at the best and worst matchups based on a PPR scoring system in fantasy football. This column will not cover the elite players in the NFL like Josh Allen, Bijan Robinson or Ja’Marr Chase. Instead, I'll look at the players who could exceed or fail to meet expectations at each position. For all of your final fantasy lineup decisions, be sure to check out my weekly player rankings, which will be updated daily throughout the 2025 NFL season.

Fab's Top 10 Fantasy Wide Receiver Rankings Week 6

1. Puka Nacua at Ravens
2. Amon-Ra St. Brown at Chiefs
3. Jaxon Smith-Njigba at Jaguars
4. Ja’Marr Chase at Packers
5. Emeka Egbuka vs. 49ers
6. Drake London vs. Bills (Mon.)
7. Deebo Samuel Sr. vs. Bears (Mon.)
8. Rome Odunze at Commanders (Mon.)
9. George Pickens at Panthers
10. Xavier Worthy vs. Lions

Complete Week 6 wide receiver rankings

Byes: Texans, Vikings

All Positions: QBs | RBs | TEs | DEFs & Ks

Week 6 Start ‘Em: Wide Receivers

Start of the Week

Tetairoa McMillan vs. Cowboys (1 p.m. ET, Fox): McMillan has yet to have a breakout game, but it could come this week against the Cowboys. Their defense has not only given up the most fantasy points to perimeter receivers, but it’s also surrendered 15-plus points to six wideouts regardless of alignment. What’s more, five scored 19-plus fantasy points and three have had 28-plus against the Boys.

Start ‘Em

Deebo Samuel Sr. vs. Bears (Mon. 8:15 p.m. ET, ABC): Samuels Sr. has been on fire in the absence of Terry McLaurin, scoring 20-plus points in each of his last two games. In that time, he’s seen a 42% target share in the offense. He also has a great matchup on Monday night against a Bears defense that’s allowed the fifth-most points per game to opposing slot receivers on the season.

Xavier Worthy vs. Lions (8:20 p.m. ET, NBC): Worthy posted a modest 11.1 fantasy points last week, but I’d keep him active in what could be a barn burner against the Lions. The total has opened as high as 50.5 (O/U), and Detroit has given up seven touchdowns and the seventh-most points to wide receivers after five weeks. Look for Worthy to rebound in this huge contest.

Ladd McConkey at Dolphins (1 p.m. ET, CBS): McConkey has not lived up to expectations to this point in the season, as he's the third-best Chargers receiver based on fantasy points. Still, he's a solid start this week against the Dolphins with Quentin Johnston injured. That means more targets for the Georgia product against a Miami defense that has been vulnerable to wideouts.

Chris Olave vs. Patriots (1 p.m. ET, CBS): Olave continues to see a ton of targets (his 54 are second behind only Puka Nacua among wideouts), so it’s only a matter of time before he has a big stat line. This could be that week, as he faces a Patriots defense that has allowed six wideouts to beat them for 12-plus points. That includes three receivers who have put up 16-plus points against them.

More Starts

• Keenan Allen at Dolphins (1 p.m. ET, CBS)
• Stefon Diggs at Saints (1 p.m. ET, CBS)
• Calvin Ridley vs. Raiders (4:05 p.m. ET, Fox)

Week 6 Sit ‘Em: Wide Receivers

Sit of the Week

Brian Thomas Jr. vs. Seahawks (1 p.m. ET, Fox): Thomas Jr. has had a tough start to the season, ranking 40th in fantasy points among wideouts. He’ll continue to be tough to trust against the Seahawks, who have allowed just two touchdowns to perimeter receivers in the first five weeks. Until the Jags can get their passing game on track, starting BTJ will come with a lot of risk in fantasy leagues.

Sit ‘Em

Zay Flowers vs. Rams (1 p.m. ET, Fox): Flowers hasn't put up bad totals over the last four weeks, but he has seen five or fewer targets in two of his last three games. He's also catching passes from Cooper Rush, not Lamar Jackson, who continues to deal with an injured hamstring. That hurts Flowers' stock, making him tough to trust against the Rams. While the matchup isn't bad on paper, I'd beware the veteran.

DJ Moore at Commanders (Mon. 8:15 p.m. ET, ABC): Moore has become a second fiddle in Chicago’s passing game behind Rome Odunze, and it shows in his fantasy point totals. In his first four games, he’s failed to score double digits three times. Moore has also been held to six or fewer targets in each game, making it pretty tough for managers to trust him on Monday night against the Commanders.

Jameson Williams at Chiefs (8:20 p.m. ET, NBC): Williams has been a massive dud in his first five games, scoring single digits in all but one of those contests. In fact, he’s been targeted five or fewer times five times, and Williams was held to just one target and one catch last week despite a plus matchup against the Bengals. I’d fade him in what is a much tougher matchup in Kansas City.

Jerry Jeudy at Steelers (1 p.m. ET, CBS): Jeudy has been mostly unstartable this season, averaging a mere 6.9 points despite being targeted 35 times in five games. And while this week’s opponents, the Steelers, have allowed the fourth-most fantasy points to perimeter receivers, I simply can’t trust him even during the bye weeks. At best, Jeudy is a flex for fantasy managers who are desperate.

More Sits

• Travis Hunter vs. Seahawks (1 p.m. ET, Fox)
• Tee Higgins at Packers (4:25 p.m. ET, CBS)
• Khalil Shakir at Falcons (Mon. 7:15 p.m. ET, ESPN)