Arizona Cardinals vs. San Francisco 49ers Betting Preview

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Meeting for the second time in three weeks, Arizona visits San Francisco to open the NFL Week 11 afternoon action. Levi’s Stadium in Santa Clara, California, is the venue for the 49ers vs. Cardinals clash at 4:05 p.m. ET on Nov. 17, 2019.

Spread: 49ers -10.5 (-110), Cardinals +10.5 (-110)

Moneyline: 49ers (-600), Cardinals (+450)

Total: OVER 45 (-110), UNDER 45 (-110)

Cardinals' Season to Date

Riding a three-game losing streak, Arizona is back on the road for a second straight week. The Cardinals (3-6-1) almost upset the Buccaneers, but gave up a late touchdown during their 30-27 loss in Tampa Bay during Week 10 action. Rookie QB Kyler Murray continues to impress as he and WR Christian Kirk connected for three TD passes.

Cardinals' Betting Record: ATS 7-3-0 OVER/UNDER 6-4-0

Cardinals' Leaders on Offense

QB Kyler Murray: 2,553 pass yards with 12 TD and 5 INT

RB David Johnson: 655 total yards with 5 TD

WR Larry Fitzgerald: 556 receiving yards with 2 TD

TE: Charles Clay: 166 receiving yards with 0 TD

49ers’ Season to Date

San Francisco (8-1) suffered its first loss of the season as Seattle posted a 27-24 OT road win in Week 10 Monday Night Football action. The 49ers were without stud TE George Kittle and lost newly acquired WR Emmanuel Sanders to a rib injury in the second quarter. San Francisco now leads Seattle by just a half game in the NFC West.

49ers’ Betting Record: ATS 5-4-0 OVER/UNDER 4-5-0

49ers’ Leaders on Offense

QB Jimmy Garoppolo: 2,054 pass yards with 14 TD and 8 INT

*RB Tevin Coleman: 501 total yards with 6 TD

WR Deebo Samuel: 339 receiving yards with 1 TD

*TE George Kittle: 541 receiving yards with 2 TD

* Lead RB Matt Breida plus TE George Kittle are both OUT with injuries.

Cardinals and 49ers Meet For The Second Time This season

Playing the back half of their 2019 NFC West Division season series, the 49ers look to make it two straight over the Cardinals. Arizona covered as a 10.5-point underdog in a 28-25 loss at home to the 49ers back in Week 9. Prior to the victory, San Francisco was on a nine-game losing streak straight up against Arizona.

49ers vs. Cardinals Final Thoughts and Pick

San Francisco let its backers down during the first meeting between these teams, as the 49ers had a 14-point lead twice. That includes a 28-14 advantage heading into the fourth quarter. Arizona covered the spread thanks to an 88-yard Kyler Murray to Andy Isabella touchdown pass with 4:53 remaining in the match.

In his first game with the Cardinals, during the Week 9 meeting vs. the 49ers, RB Kenyan Drake had a big night as he posted 162 total yards and one TD. Drake came back down to earth last week, though, as he managed just 41 total yards against the stout Tampa Bay defence. The 49ers are on a short week and have mounting injuries. Back Arizona with the points.

Pick: Cardinals +10.5

Season Record: 1-12