Leonard Fournette had 41 rushing yards in the season opener before heading to the locker room.
Leonard Fournette left Sunday's 20–15 win against the Giants early.
He went to the locker room in the first half with a hamstring injury and did not return during the second half.
The second-year running back was holding his right hamstring when he left the contest against the Giants during the second quarter.
Prior to his exit, Fournette had rushed for 41 yards on nine carries and had three catches for 14 yards.
With Fournette out of the game, Jacksonville relied on T.J. Yeldon to handle the load in the backfield. Yeldon had three rushes for 22 yards and two catches for eight yards and the game's first touchdown in the first half.
Yeldon finished with 14 carries for 51 yards and three receptions with one touchdown.