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Nov 30, 2025; Indianapolis, Indiana, USA; Indianapolis Colts running back Jonathan Taylor (28) warms up before a game against the Houston Texans at Lucas Oil Stadium.

Christian McCaffrey, Jonathan Taylor And 3 More PrizePicks Plays For 49ers Vs. Colts

Ethen Hutton

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2 Hours Ago

Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers wide receiver Jauan Jennings (15) enters the field prior to the first half against the Tennessee Titans at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

Perfect Week 16 MNF FanDuel DFS Lineup: Stack Elite 49ers', Including Jauan Jennings

Thomas Carelli

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5 Hours Ago

Oct 12, 2025; Tampa, Florida, USA: Tampa Bay Buccaneers wide receiver Emeka Egbuka (2) runs for a gain past San Francisco 49ers linebacker Tatum Bethune (48) during the second quarter at Raymond James Stadium. Mandatory Credit: Jonathan Dyer-Imagn Images

49ers Counting on Run Defense Changes vs. Colts

Tom Jensen

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4 Hours Ago

Philip Rivers will look to keep the Colts’ slim playoff chances afloat on Monday night against the 49ers.

Colts vs. 49ers: Three Bold Predictions for ‘Monday Night Football’ in Week 16

Karl Rasmussen

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6 Hours Ago

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Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers head coach Kyle Shanahan looks on during the fourth quarter against the Tennessee Titans at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

Why this 49ers' place on the depth chart may not reflect his value

Henry Cheal

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7 Hours Ago

Key starters expected to return for San Francisco 49ers in Week 16

Parker Hurley

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8 Hours Ago

Dec 7, 2025; Jacksonville, Florida, USA;Indianapolis Colts tight end Tyler Warren (84) leaves the field after a loss to the Jacksonville Jaguarsat EverBank Stadium.

Tyler Warren, Jauan Jennings, and 3 Other Underdog Player Props For Colts vs. 49ers

Gray Deyo

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9 Hours Ago

San Francisco 49ers tight end George Kittle is a great prop target on Monday.

Best NFL Picks and Predictions Today (How to Bet 49ers vs. Colts on Monday Night Football in NFL Week 16)

Peter Dewey

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10 Hours Ago

How Elaborate NFL Gift Giving Became an Arms Race

Greg Bishop

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10 Hours Ago

Highly paid quarterbacks such as Joe Burrow are now expected to give teammates expensive gifts. But how does it really work?

The 20 Unwritten Rules of NFL Gift Giving

Greg Bishop

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7:58 AM EST

San Francisco 49ers running back Christian McCaffrey is a great prop target in Week 16.

49ers vs. Colts Best Anytime Touchdown Scorer Picks for Monday Night Football in NFL Week 16

Peter Dewey

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7:45 AM EST

Indianapolis Colts running back Jonathan Taylor is a great prop target in Week 16.

49ers vs. Colts Best NFL Prop Bets for Monday Night Football in Week 16 (Bet on Jonathan Taylor)

Peter Dewey

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7:15 AM EST

The San Francisco 49ers and quarterback Brock Purdy are favored on Monday.

49ers vs. Colts Final Score Prediction for NFL Week 16 (Can 49ers Cover on Road?)

Peter Dewey

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6:00 AM EST

Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers quarterback Mac Jones (10) warms up in the second half against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images

Why the 49ers Can’t Afford to Lose Mac Jones in 2026

Henry Cheal

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Dec 21, 2025

Robert Saleh reveals the secret ingredient for the 49ers defense

Parker Hurley

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Dec 21, 2025

Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers defensive coordinator Robert Saleh looks on in the third quarter against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images

49ers must fix this issue in final three games to secure No. 1 Seed

Henry Cheal

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Dec 21, 2025

One must-start in fantasy football on the San Francisco 49ers

Parker Hurley

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Dec 21, 2025

Brandon Aiyuk posts alarming video speeding past 49ers facility

Grant Cohn

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Dec 20, 2025

Nov 30, 2025; Cleveland, Ohio, USA; The San Francisco 49ers huddle up after the break during the second half against the Cleveland Browns at Huntington Bank Field. Mandatory Credit: Scott Galvin-Imagn Images

49ers Will be Without Two Skilled Starters Against Indianapolis

Jose Sanchez

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Dec 20, 2025

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