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Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers wide receiver Ricky Pearsall (1) stiff arms Tennessee Titans cornerback Marcus Harris (26) during the third quarter at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

Four 49ers Pop up on First Injury Report for Week 16

Jose Sanchez

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Dec 18, 2025

Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers tight end George Kittle (85) celebrates scoring a touchdown during the third quarter against the Tennessee Titans at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images

How the 49ers can Clinch a Playoff Berth in Week 16

Jose Sanchez

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Dec 18, 2025

Seahawks quarterback Sam Darnold celebrates with Jalen Milroe after leading Seattle to an overtime victory over the Rams on Thursday night to clinch a playoff berth.

2025 NFL Playoff Picture and Clinching Scenarios for Week 16

Matt Verderame

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Dec 18, 2025

Why 49ers' Robert Saleh is the NFL's top head-coach candidate

Parker Hurley

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Dec 18, 2025

Schedule

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This group must continue to ascend for 49ers in Week 16

Parker Hurley

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Dec 18, 2025

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts running back Jonathan Taylor (28) rushes against the Seattle Seahawks during the first half at Lumen Field. Mandatory Credit: Steven Bisig-Imagn Images

5 Keys for Philip Rivers, Colts to Beat 49ers Under the Bright Lights

Drake Wally

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Dec 18, 2025

Ohio State linebacker Arvell Reese (8) and defensive end Kenyatta Jackson Jr. are two of SI's top 100 ranked prospects.

Nine Ohio State Players Dominate SI’s 2026 Top 100 NFL Draft Prospect Rankings

Daniel Flick

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Dec 18, 2025

Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) prepares to pass the ball during the first quarter against the Tennessee Titans at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images

How Brock Purdy's Return Has Shifted the 49ers' Locker Room Dynamic

Henry Cheal

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Dec 17, 2025

Two Stats Prove This Is George Kittle’s Best Season With the 49ers

Henry Cheal

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Dec 17, 2025

Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers defensive coordinator Robert Saleh speaks with 49ers safety Malik Mustapha (6) in the third quarter against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images

How the 49ers’ Defense can Easily Shutdown the Colts

Jose Sanchez

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Dec 17, 2025

Oct 26, 2025; Indianapolis, Indiana, USA; Indianapolis Colts running back Jonathan Taylor (28) celebrates after scoring a touchdown during the third quarter against the Tennessee Titans at Lucas Oil Stadium.

Jonathan Taylor, More Running Backs Reign Supreme in 2026 Fantasy Football Mock Draft

Ryan Shea

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Dec 17, 2025

Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers tight end George Kittle (85) scores a touchdown during the third quarter against the Tennessee Titans at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

Three Plays That Heavily Influenced the 49ers' Win Against Tennessee

Jose Sanchez

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Dec 17, 2025

Dec 14, 2025; Santa Clara, California, USA; Tennessee Titans running back Tony Pollard (20) runs with the ball during the second quarter against the San Francisco 49ers at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

One Area That is Becoming a Weakness for the 49ers

Jose Sanchez

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Dec 17, 2025

The Dolphins fell to 6–8 after a loss to the Steelers and will miss the postseason.

Is the Tua Tagovailoa–Mike McDaniel Era Over in Miami?

Albert Breer

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Dec 17, 2025

These San Francisco 49ers should make the 2025 Pro Bowl

Parker Hurley

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Dec 17, 2025

Philip Rivers will make his second start of the season against the 49ers.

49ers vs. Colts Prediction, Odds, Spread, Injuries, Trends for NFL Week 16

Iain MacMillan

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Dec 17, 2025

The ideal playoff seed for the 49ers' Super Bowl hopes

Parker Hurley

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Dec 17, 2025

Seattle Seahawks wide receiver Jaxon Smith-Njigba is the favorite to win the OPOY award.

NFL Offensive Player of the Year Odds: Jaxon Smith-Njigba Set as Major Favorite Ahead of Week 16

Peter Dewey

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Dec 17, 2025

Tom Brady, Adrian Peterson, and Joe Burrow havev all gone onto have success post-ACL tear.

How NFL Stars Have Performed Post-ACL Tear in Wake of Mahomes, Parsons Injuries

Mike Kadlick

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Dec 17, 2025

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