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San Francisco 49ers quarterback Brock Purdy could miss the team's Week 2 game, moving the odds in a big way.

49ers vs. Saints Odds Shift Again Following Latest Brock Purdy Injury Update

Peter Dewey
|
Sep 10, 2025
Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers tight end George Kittle (85) celebrates after scoring a touchdown during the first half against the Seattle Seahawks during the first quarter at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

Why George Kittle's hamstring injury is a major concern for the 49ers

Henry Cheal
|
Sep 10, 2025
Sep 7, 2025; Seattle, Washington, USA; The San Francisco 49ers celebrate after a fumble recovery during the second half against the Seattle Seahawks during the fourth quarter at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

San Francisco 49ers Among Best Fantasy Football Week 2 Defense Streamers

Michael Rovetto
|
Sep 10, 2025
Sep 7, 2025; Atlanta, Georgia, USA; Tampa Bay Buccaneers linebacker Lavonte David (54) tackles Atlanta Falcons wide receiver Drake London (5) as he runs out of bounds during the second quarter at Mercedes-Benz Stadium. Mandatory Credit: Brett Davis-Imagn Images

Fantasy Football Week 2 Injury Updates Including Xavier Worthy And Drake London

Thomas Carelli
|
Sep 14, 2025
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The Sports Illustrated team breaks down their picks to win all 16 games in Week 2 of the 2025 NFL season.

NFL Straight-Up Moneyline Picks for Every Game in Week 2

SI Staff
|
Sep 10, 2025

This QB could be Kyle Shanahan's latest successful reclamation project

Parker Hurley
|
Sep 10, 2025

This rookie may already be a problem for the 49ers

Parker Hurley
|
Sep 10, 2025

Jul 30, 2025; New Orleans, LA, USA;  New Orleans Saints defensive end Cameron Jordan (94) during training camp at Ochsner Sports Performance Center. Mandatory Credit: Stephen Lew-Imagn Images

Cam Jordan Will Make Saints History Vs. 49ers

Patrick McAvoy
|
Sep 10, 2025

Oct 13, 2024; Charlotte, North Carolina, USA; Carolina Panthers place kicker Eddy Pineiro (4) during the second half at Bank of America Stadium. Mandatory Credit: Jim Dedmon-Imagn Images

Eddy Pineiro Plus Two More Kickers to Stream for Fantasy Football Week 2

Chris Wassel
|
Sep 10, 2025
Aug 9, 2025; Santa Clara, California, USA;  San Francisco 49ers offensive lineman Connor Colby (75) pass protects San Francisco 49ers quarterback Tanner Mordecai (4) against Denver Broncos defensive lineman Jordan Jackson (94) in the second quarter at Levi's Stadium. Mandatory Credit: David Gonzales-Imagn Images

One Starting Lineup Change the 49ers Should Make Against the Saints

Jose Sanchez
|
Sep 10, 2025

Arizona Diamondbacks manager Torey Lovullo reacts during action against the Cleveland Guardians in the third inning at Chase Field on Aug. 20, 2025.

D-backs Manager Gave Honest Statement on Poor Umpiring

Alex D'Agostino
|
Sep 10, 2025

Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers quarterback Brock Purdy (13) looks on during the first half against the Seattle Seahawks at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

How 49ers' Brutal Injury News Impacts Saints, Spencer Rattler

Patrick McAvoy
|
Sep 10, 2025

Buffalo Bills quarterback Josh Allen (17) celebrates the come-from-behind victory over the Baltimore Ravens.

On SI NFL Power Rankings: Who’s No. 1 After Week 1?

Bill Huber
|
Sep 10, 2025

Jan 5, 2025; Glendale, Arizona, USA; Detailed view of a San Francisco 49ers helmet at State Farm Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images

49ers Sign Former Jets Specialist

Patrick McAvoy
|
Sep 10, 2025

Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers tight end George Kittle (85) celebrates after scoring a touchdown during the first half against the Seattle Seahawks during the first quarter at Lumen Field.

San Francisco 49ers Designate George Kittle To IR Following Hamstring Injury

Ethen Hutton
|
Sep 10, 2025

Bears quarterback Caleb Williams showed some improvement during Chicago's Week 1 loss to the Vikings.

Why Bears Fans Shouldn’t Panic, and How the 49ers Can Survive Their Early Injuries

Gilberto Manzano
|
Sep 10, 2025

Oct 6, 2024; Santa Clara, California, USA; San Francisco 49ers place kicker Jake Moody (4) prepares to kick a field goal against the Arizona Cardinals during the second quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images

The Lesson the 49ers Should Learn From the Jake Moody Blunder

Jose Sanchez
|
Sep 9, 2025

Sep 29, 2024; Charlotte, North Carolina, USA;  Carolina Panthers place kicker Eddy Pineiro (4) kicks a field goal in the fourth quarter at Bank of America Stadium

Eddy Piñerio, 49ers Agree to Deal After Jake Moody Release

Duke Demming
|
Sep 9, 2025

Jan 5, 2025; Glendale, Arizona, USA; San Francisco 49ers place kicker Jake Moody (4) reacts after missing a field goal in the first half against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images

49ers Find Their Replacement for Jake Moody

Jose Sanchez
|
Sep 9, 2025
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© 2025 ABG-SI LLC - SPORTS ILLUSTRATED IS A REGISTERED TRADEMARK OF ABG-SI LLC. - All Rights Reserved. The content on this site is for entertainment and educational purposes only. Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Sports Illustrated or its affiliates, licensees and related brands. All picks and predictions are suggestions only and not a guarantee of success or profit. If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER.