Sharp went down immediately after the hit and was unable to put weight on his right knee. He required assistance to exit the ice and did not return to the game.
Quenneville said Sharp's absence was a loss for the team, but may provide some opportunities to other players.
"Miss a guy like Sharpie, you miss some production, miss some consistency in a lot of areas," Quenneville said on Thursday.
"At the same time, it's a good opportunity for some guys that are looking and want more."
Through 13 games this season, Sharp has three goals and six assists, as well as 56 shots on goal.
He has 236 goals and 256 assists in 690 games during his 13-year career, 10 seasons of which he has spent in Chicago.
The Blackhawks are 7-5-1 this season, and sit in fourth place in the Western Conference's Central Division. They face the Washington Capitals at home on Friday.