Williamson sustained the injury just over 30 seconds into the game. The 6'7", 275-pound forward lost possession of the ball near the top of the key as he slipped and ripped through his shoe.
Williamson grabbed the back of his leg following the play before departing for the locker room. Per ESPN's Maria Taylor, Williamson was accompanied by family members in the locker room.
Williamson entered Wednesday as Duke's second-leading scorer, averaging 22.4 points per game.