Kendricks, 23, missed last week's game against Washington with the injury. In two games this season, he has 10 tackles and one sack.
His 86 tackles last season were the second-most on the team. He also had four sacks, three interceptions, and four fumble recoveries.
Philadelphia is allowing 386 yards per game this season, which ranks 28th in the league.
Mosher also reports wide receiver Josh Huff is questionable, while offensive tackle Matt Tobin and defensive end Fletcher Cox are probable.
The Eagles are 3-0 and play the 49ers on the road on Sunday at 4:25 p.m. ET.
- Paul Palladino