Colts to Avoid Two Top Titans Leaders This Afternoon

The Tennessee Titans will be without two of their most important players when the Indianapolis Colts defend home turf.

Oct 5, 2025; Glendale, Arizona, USA; Tennessee Titans wide receiver Calvin Ridley (0) makes a catch against the Arizona Cardinals during the second quarter at State Farm Stadium. Mandatory Credit: Joe Camporeale-Imagn Images | Joe Camporeale-Imagn Images

The Indianapolis Colts are the best team in the NFL, sitting at an impressive 6-1 record. However, they'll face off against the Tennessee Titans, who are one of the worst teams in the NFL at an exact opposite 1-6 record.

Given the matchup on paper, many would assume the Colts can take care of the Titans to sweep their AFC South rival this afternoon at Lucas Oil Stadium, but anything can happen in the NFL, especially when it comes to divisional tilts.

With a chance to get to 7-1 on the year for the Colts ahead, it's time to take a brief look over the inactives for Indianapolis and Tennessee.

Colts Inactives

our inactives for #TENvsIND. pic.twitter.com/mUE39ORkEF

— Indianapolis Colts (@Colts) October 26, 2025

The names that stand out the most are defensive ends Samson Ebukam and Tyquan Lewis. Ebukam (MCL) and Lewis (groin) were injured during Indy's Week 7 matchup with the Los Angeles Chargers, leaving the game to not return.

After this happened, the Colts elevated defensive end Durell Nchami to the active roster to give their defensive edge room depth. The Colts will want to get after Cam Ward as much as possible, given that he has sustained 102 pressures and 30 sacks.

Laiatu Latu, Kwity Paye, and J.T. Tuimoloau have a massive opportunity to wreak havoc on Ward, opening up chances to secure potential turnovers.

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Titans Inactives

Today’s Inactives #TENvsIND pic.twitter.com/D3PbHjL1cv

— Titans PR (@TitansPR) October 26, 2025

As for the Titans, they'll miss two huge contributors: Wide receiver Calvin Ridley and defensive tackle Jeffery Simmons.

Starting with Ridley, even though the Titans' offense has been nonexistent, the veteran is still the most gifted of the pass-catchers for Ward to lean on. Ridley has 16 catches for 290 receiving yards and 12 first downs through six games.

Given how decimated with injuries the Colts' defensive secondary is, this will help Lou Anarumo's cornerbacks get through a divisional clash that can give Indy a 2-0 record in the AFC South.

As for Simmons missing the game, this points directly at a potentially big game from Jonathan Taylor. Last time the Colts played Tennessee, Taylor went off for 118 all-purpose yards (102 rushing yards, 16 receiving yards) and three touchdowns.

We'll see how much the Colts can take advantage of Tennessee not having one of their most important offensive and defensive assets when they take the field at 4:25 EST from Lucas Oil Stadium in an attempt to sweep the series with the Titans.

"Jonathan Taylor right now should be OPOY" 🏆@M_Ryan02 says the @Colts will have to rely on their star RB down the stretch this season pic.twitter.com/6h7QeO9T7P

— NFL on CBS 🏈 (@NFLonCBS) October 26, 2025