Rams vs 49ers Live Game Thread

INGLEWOOD, CA -- The Los Angeles Rams are taking on the San Francisco 49ers at home for the second week in a row. The Rams are currently undefeated at home after they handed the Indianapolis Colts their first loss of the season.

This is the first divisional game of the year for the Rams, and both the Rams and the 49ers have the same exact record. The 49ers will be without Brock Purdy, George Kittle, Brandon Aiyuk, Jauan Jennings, and Ricky Pearsall.

Looking Ahead

Their offense is depleted, which the Rams' defense should take advantage of. Expect Jared Verse to have a big game against Mac Jones and the 49ers' offensive line, as with not many receivers to turn to, he'll be forced to look harder for open pass-catchers, which allows more time for the Rams defense to get home with how much pressure they've been getting to start the season.

One of the biggest things to look out for in this game will be if Puka Nacua can continue the historic start he's had to his 2025 campaign. He hasn't had a game this season under 100 yards. It'll be interesting to see if the 49ers commit to stopping that streak.

Matthew Stafford has already shown he can distribute the ball to plenty of his pass-catchers, and if the 49ers overcommit to Nacua, Davante Adams, and Tutu Atwell will be there to punish them for it. Another thing to look out for will be the Rams' ground game, as it's had a quiet start, but can take over the game if the Rams consistently hand the ball off to Kyren Williams.

The 49ers' defense has been playing admirably to start the season, with them only allowing eight touchdowns so far throughout the season. They're also top ten in points allowed and offensive passing yards.

Sep 28, 2025; Inglewood, California, USA; Los Angeles Rams running back Kyren Williams (23) and wide receiver Puka Nacua (12) flex as they get ready for the game against the Indianapolis Colts at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images | Jayne Kamin-Oncea-Imagn Images

This may be a game where the Rams can't air the ball out as much as they'd like, which is why there's such an emphasis on the ground game. If they let their defense make big plays and let the run game control the pace and clock, they have an amazing opportunity to win against their divisional rival and get some serious leg room in the NFC West.

The game kicks off at 8:15 PM EST/ 5:15 PM PST and can be watched on Amazon Prime Video!

Be sure to follow along with our live game thread for updates throughout the contest.

START OF THE FIRST QUARTER:

PENALTY: 49ers OL Connor Colby's false start penalty was accepted by the Rams for a five-yard loss

PENALTY: 49ers OL Colton McKivitz's offensive holding penalty was accepted for a ten-yard loss

BIG PLAY: 49ers QB Mac Jones gets the ball to WR Kendrick Bourne, who gets 32 yards after the catch for a big chunk play

SCORING UPDATE: Mac Jones hits TE Jake Tonges for a quick six-yard touchdown catch, 49ers lead 7 - 0

SACK: 49ers DE Bryce Huff takes down Rams QB Matthew Stafford for an 11-yard loss

PENALTY: Rams LB Josaiah Stewart with a late hit on Mac Jones, which added 15 yards due to a roughing the passer penalty to a 13-yard catch from 49ers WR Demarcus Robinson

END OF THE FIRST QUARTER: 49ers lead 7 - 0

START OF THE SECOND QUARTER:

SCORING UPDATE: 49ers RB Christian McCaffrey catches a one-yard touchdown catch, 49ers lead 14 - 0

TURNOVER: Rams RB Blake Corum fumbles the ball, recovered by 49ers LB Trevis Gipson

PENALTY: Rams OL Alaric Jackson's false start penalty takes the Rams offense back five yards

PENALTY: 49ers DB Deommodore Lenoir's defensive holding on Rams WR Davante Adams gives the Rams offense five yards

SCORING UPDATE: Matthew Stafford connects with Rams RB Kyren Williams for a 14-yard touchdown catch, Rams cut the lead 14 - 7

2 MINUTE WARNING

INJURY: Rams LB Nate Landman is down with an injury

INJURY UPDATE: Nate Landman is back on the field

SCORING UPDATE: 49ers nail a 37-yard field goal to go up 17 - 7

HALFTIME: 49ers lead 17 - 7

START OF THE THIRD QUARTER:

BIG PLAY: Rams kicker Joshua Karty misses a 53-yard field goal

INJURY: 49ers DT Kalia Davis is out for the game

PENALTY: Rams CB Darious Williams with an untimely defensive pass interference penalty

INJURY: Mac Jones goes down on the field with a leg injury

SCORING UPDATE: 49ers kick a 20-yard field goal, 49ers go up 20 - 7

INJURY UPDATE: Mac Jones is able to jog off the field

BIG PLAY: Matthew Stafford finds WR Tutu Atwell for a 34-yard gain

INJURY: 49ers DE Yetur Gross-Matos exits the game with an injury

SCORING UPDATE: Matthew Stafford throws a quick pass to WR Puka Nacua for a one-yard touchdown, Rams cut the lead 20 - 14

PENALTY: Colton McKivitz's false start penalty costs the 49ers five yards

BIG PLAY: Rams head coach Sean McVay throws a challenge flag on a third-down conversion, and the play is reversed

BIG PLAY UPDATE: On the next play, the 49ers convert on fourth down, continuing their drive

END OF THE THIRD QUARTER: 49ers lead 20 - 14

START OF THE FOURTH QUARTER:

BIG PLAY: Nate Landman stuffs Christian McCaffrey for a loss of three yards, forcing the 49ers to punt

INJURY UPDATE: Yetur Gross-Matos is out for the game

PENALTY: Deommodore Lenoir's defensive holding penalty gives the Rams a fresh set of downs

SCORING UPDATE: Kyren Williams catches an eight-yard touchdown pass, his second touchdown catch of the game; however, Joshua Karty's extra point attempt gets blocked, and the game is tied 20 - 20

BIG PLAY: Rams 59-yard punt pins the 49ers deep in their territory

PENALTY: Mac Jones' ineligible downfield pass costs the 49ers five yards

SCORING UPDATE: 49ers drill a 59-yard field goal, they lead 23 - 20

PENALTY: Deommodore Lenoir with another defensive holding penalty, gives the Rams a fresh set of downs as well as five yards

2 MINUTE WARNING

BIG PLAY: Kyren Williams runs for a 20-yard gain

PENALTY: 49ers DE Mykel Williams' illegal use of the hands penalty gives the Rams a fresh set of downs

TURNOVER: Kyren Williams fumbles the ball at the one-yard line, 49ers DL Alfred Collins recovers

PENALTY: Rams CB Tre Brown's offensive holding penalty on the punt negates a big return

BIG PLAY: Kyren Williams catches a 13-yard pass to convert a huge fourth down

SCORING UPDATE: Rams kick a 48-yard field goal to tie the game as time expires. They tie the game 23 - 23

OVERTIME:

PENALTY: Joshua Karty couldn't get the ball in the kicking zone, setting up the 49ers at the 40-yard line

SACK: Rams LB Bryon Young takes down Mac Jones for a nine-yard sack

SCORING UPDATE: 49ers doink a 41-yard field goal, which goes in to take the lead 26 - 23

BIG PLAY: Matthew Stafford bombs it downfield for Tutu Atwell for a 38-yard gain

TURNOVER: The 49ers stuff Kyren Williams on fourth down, ending the game

FINAL SCORE: 26 - 23, Rams lose