Rams vs 49ers Live Game Thread

SANTA CLARA, CA -- The Los Angeles Rams will be taking on the San Francisco 49ers for the second time this season, this time, the game being played on the 49ers' home turf. The last time these two teams played, the 49ers handed the Rams their second loss of the season in a surprising turn of events.

The usually stout Rams defense was unable to stop Mac Jones and Kendrick Bourne from torching their secondary, and they couldn't get a stop when the game was on the line. Though it's only been five weeks since their last encounter, this is not the same Rams team as before. They're much more polished than the team they were before, and they have much more time to prepare for the 49ers this time around.

Different Week, Different Team

Nov 2, 2025; Inglewood, California, USA; Los Angeles Rams defensive end Kobie Turner (91) leaves the field following a game against the New Orleans Saints at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images | Jayne Kamin-Oncea-Imagn Images

One of the biggest differences about this Rams team as opposed to the last time these two teams met is that Puka Nacua is healthy now, which means the Rams offense has access to one of its top players. Matthew Stafford and Nacua have been on point in each game they've played together. He should be a huge addition to their game plan in week 10.

He should be on a snap count due to how last week panned out with him having to leave the game early, but his just being on the field changes the dynamics of the 49ers defense so much. Another thing that differs about their offense for their week 10 matchup is the offense evolution the Rams have undergone to adapt to Nacua's absence from the lineup.

October 19, 2025; Santa Clara, California, USA; San Francisco 49ers tight end George Kittle (85) before the game against the Atlanta Falcons at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images | Kyle Terada-Imagn Images

They've been using an increased number of tight ends in their plays and offensive formations, which has led to their offense having more cohesion than ever this season. Of course, that's not to say the 49ers don't have their own things going for them. George Kittle will be available for them; they're still dealing with a ridiculous amount of injuries, but he's one of their top playmakers.

However, this game has so many more stakes now for the Rams that they made this a must-win scenario for them. If they go down 0 - 2 in divisional games this season, their hopes of becoming consecutive NFC West champions are down the drain. They cannot allow the 49ers to upset them once again, as this is the most important game of their season halfway through.

The game kicks off at 1:25 PM PST / 4:25 PM EST and can be watched on FOX Sports!

Be sure to follow along with our live game thread for updates throughout the contest.

START OF THE FIRST QUARTER:

SCORING UPDATE: Rams RB Kyren Williams walks it in for a 2-yard touchdown, Rams up 7 - 0

PENALTY: 49ers DE Clelin Ferrell committed a defensive offside penalty, giving the Rams 5 yards

BIG PLAY: Rams QB Matthew Stafford zips a throw to WR Davante Adams for a 23-yard catch

INJURY: 49ers LB Tatum Bethune goes down with an injury

SCORING UPDATE: Stafford throws a screen pass to WR Puka Nacua, who ran it in for a 22-yard touchdown reception, Rams up 14 - 0

PENALTY: 49ers WR Jauan Jennings commits a false start penalty

TURNOVER: Rams CB Kamren Kinchens recovers a fumble, which was dislodged from Jennings by Rams LB Nate Landman

END OF THE FIRST QUARTER: Rams lead 14 - 0

SCORING UPDATE: Stafford lays the ball in for Rams TE Davis Allen for a 4-yard touchdown catch, Rams up 21 - 0

TURNOVER: The 49ers hand it off to RB Christian McCaffrey in the red zone, but the Rams defense holds firm, and they turn the ball over on downs

PENALTY: The 49ers' defense had too many men on the field, a 5-yard defensive penalty that benefits the Rams' offense

SCORING UPDATE: Jennings catches a 6-yard touchdown catch to get the 49ers on the scoreboard, Rams lead 21 - 7

SACK: 49ers Kalia Davis takes down Stafford for a 5-yard sack

2 MINUTE WARNING

PENALTY: In the two-minute drill, the 49ers commit a delay of game penalty, which sets them back 5 yards

HALFTIME: Rams up 21 - 7

START OF THE THIRD QUARTER:

BIG PLAY: 49ers QB Mac Jones completes a short pass to McCaffrey, which he converts into a 19-yard gain

SCORING UPDATE: 49ers RB Brian Robinson Jr. runs it in for a 1-yard touchdown, Rams up 21 - 14

PENALTY: Bethune's unnecessary roughness penalty on Williams gives the Rams an additional 15 yards

BIG PLAY: Stafford connects with Nacua on 4th down to continue the drive

SCORING UPDATE: Stafford throws to Adams in the red zone, which results in a touchdown, Rams up 28 - 14

BIG PLAY: 49ers WR Kendrick Bourne gets going with his first reception, a 19-yard catch

END OF THE THIRD QUARTER: Rams up 28 - 14

START OF THE FOURTH QUARTER:

SCORING UPDATE: Jones connects with 49ers WR Luke Farrell on a scramble play for a 9-yard touchdown, but the extra point was blocked, Rams up 28 - 20

BIG PLAY: Stafford slings it to TE Terrance Ferguson for a 32-yard play

SCORING UPDATE: Williams runs it in for a 7-yard touchdown run, his second of the game, Rams up 35 - 20

TURNOVER: Rams CB Emmanuel Forbes Jr. picks off Jones for the first interception of the game

SCORING UPDATE: Stafford throws for his 4th touchdown of the day, this time going to TE Colby Parkinson on a 16-yard reception, Rams up 42 - 20

PENALTY: Jennings commits an illegal formation penalty

SCORING UPDATE: 49ers TE George Kittle lays it out for a 13-yard touchdown catch, but the 2-point conversion failed, Rams up 42 - 26

PENALTY: Stafford gets the 49ers defense to jump with his cadence

2 MINUTE WARNING

VICTORY FORMATION: Stafford kneels the ball, securing the win for the Rams.

END OF THE GAME

The Rams beat the 49ers 42 - 26, propelling them to 7 - 2.