Ghana has beaten the United States in the last two World Cups, knocking the Americans out in the round of 16 in South Africa in 2010 and eliminating them in the group stage in 2006 in Germany.
So the Black Stars are confident heading into their Group G opener against the U.S. on Monday.
"If we are fit and we are all 100 percent there is no way that we aren't going to win this game," said Ghanaian midfielder Andre Ayew, who played in the 2010 win over the U.S. "We have won twice. And as we say there is no two without three, so we want to try and beat them for the third time."
The two World Cup matches between the countries are the only two times they have played each other.
Ayew, 24, has four career international goals in 48 appearances and plays for the French club Marseille. Despite his assertion that Ghana will win so long as it's fit, he knows the United States will come out looking for revenge.
"I think if you are a team and you lose twice vs. a country, say Ghana, as in 2006 and in 2010, if you have the opportunity to meet them in 2014, I think you do everything to beat them," he said of the match set for rainy Natal. "Not just for them but for their pride and for their country."
World powers Germany and Portugal are also in Group G with Ghana and the U.S.
Said U.S. goalie Tim Howard of Ghana: "I think they are very similar [to 2010]. They are strong individually. Obviously, we know how physical they are so we are going to try to match that. I've said it before, very rarely do we get outmatched physically but this is a team that has the possibility of doing that."SI WIRE: Spain’s Xavi Hernandez: Loss to Netherlands ‘hardest loss of my career’