Pregame Report: Chargers at Cardinals Week 12

The Chargers will take on the Cardinals in Week 12 at State Farm Stadium.

The Chargers (5-5) and Cardinals (4-7) will face off in Week 12 with both teams desperately needing to secure a victory.

Here's a look at the Week 12 pregame report, previewing the Chargers' matchup against the Cardinals.

Date, time and location

• Sunday, Nov. 27 at 5:20 p.m. PT
• State Farm Stadium

How to watch and listen

• TV: CBS
• Radio: ATL FM-98.7, featuring Matt "Money" Smith, Daniel Jeremiah and Shannon Farren

Where to stream

• NFL Sunday Ticket, FuboTV

Final injury report

Chargers:

• OUT: WR Mike Williams, S Nasir Adderley
• QESTIONABLE: CB Michael Davis

Cardinals:

• OUT: TE Zach Ertz, OL D.J. Humphries, WR Rondale Moore, CB Byron Murphy Jr., S Charles Washington
• QESTIONABLE: WR Greg Dortch, QB Trace McSorley

Betting odds

• Point spread: Chargers -2.5
• Moneyline: Chargers (-150), Cardinals (+125)
• Over/under: 48.5 points

*All betting odds are courtesy of Sports Illustrated Sportsbook.

Things to watch

• How the Chargers offensive line fares against the blitz: The Cardinals defense sits near the top of the league in blitz rate, while the Chargers offense line has allowed just 18 sacks this season, tied for the third-best in the NFL. However, last week the Chargers had their worst game of the season in preventing the pass rush from bringing Justin Herbert to the ground, allowing a season-high five sacks. This battle in the trenches will likely play a pivotal part in the outcome of the game.
• Can Joshua Palmer continue his hot streak of late?: The Chargers have turned to their second-year pass-catcher in slew of the injuries to the wide receiver position. With Keenan Allen back into the mix, Palmer slides down a spot as the second option. But as Mike Williams is ruled out with an ankle injury, Palmer figures to remain a steady part of the gameplan. In two of the last three games, Palmer has gone over 100 yards receiving with two touchdowns.
• Containing Kyler Murray: This week in practice, the Chargers have prioritized game-planning for Murray's mobility. Third-string quarterback Easton Stick has served the 'Murray role' on the scout team, giving the Chargers defense a simulated look at what they've presumably face on Sunday. Murray is one of the more unique players in the league in part of his 4.3-speed and his knack for being slippery through tacklers despite not being the biggest guy. For the Chargers defense to hold things to a minimum, they must keep Murray contained in the pocket.

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Read more from Charger Report:

• Chargers at Cardinals Game Day Betting Odds: Week 12 Point Spread, Moneyline, Over/Under
• Chargers at Cardinals Week 12 Game Prediction
• Chargers Turn Towards Reserve Options at Safety Following Thumb Injury to Nasir Adderley
• Chargers at Cardinals Week 12 Injury Report: Friday
• Chargers RB Joshua Kelley Nearing Return Following Knee Injury

Nick Cothrel is the publisher of Charger Report. Follow Nick on Twitter @NickCothrel for more Chargers coverage.