Colts List Four Starters on Early Injury Report

The Indianapolis Colts released their first injury report ahead of a Week 6 clash against the Arizona Cardinals.

Indianapolis Colts cornerback Kenny Moore II (23) high fives Indianapolis Colts cornerback Samuel Womack III (33) after making an interception at the end of the game Sunday, Dec. 22, 2024, during a game against the Tennessee Titans at Lucas Oil Stadium in Indianapolis. / Christine Tannous/IndyStar / USA TODAY NETWORK via Imagn Images

As the Indianapolis Colts continue preparations for this weekend's matchup against the Arizona Cardinals, several players are battling injuries that could impact the team's game-day roster.

The Colts were without multiple key starters against the Las Vegas Raiders last Sunday, but early indications show that Indy could be getting one of those players back against Arizona.

Colts' Injury Report

• RB Tyler Goodson (Groin) - DNP
• DE Tyquan Lewis (Illness) - DNP
• CB Kenny Moore II (Achilles) - DNP
• T Braden Smith (Rest) - DNP
• DT Grover Stewart (Biceps) - FULL
• WR Alec Pierce (Concussion) - FULL

wednesday's practice report for #AZvsIND. pic.twitter.com/fN2HJZKAMK

— Indianapolis Colts (@Colts) October 8, 2025

Goodson missed the first two games of the season due to an elbow injury before suffering a groin injury in Week 4's clash against the Los Angeles Rams. Running back Jonathan Taylor has been the workhorse in the backfield, with rookie DJ Giddens behind him.

Lewis was on last week's injury report due to an oblique injury, but he fought through the issue to suit up against Vegas. He recorded one sack, bringing down Geno Smith in the red zone to help hold the Raiders to a field goal in the first quarter.

Moore has now sat out seven consecutive practices due to an Achilles injury. Moore exited the team's Week 3 win against the Tennessee Titans in the fourth quarter, just hours after he recorded a pick-six to open the scoring.

With the Colts' secondary losing Mike Hilton to practice squad IR, the quicker Moore returns (without re-aggravating his injury), the better.

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Smith took a well-deserved rest day after helping hold the Raiders' defense to zero sacks. Smith struggled on Indy's opening drive, but he settled down nicely and limited the impact of star defensive end Maxx Crosby.

Stewart suffered his injury in Sunday's win, but his full participation on Wednesday is a good indication that he'll play against the Cardinals this weekend. Stewart had a pass deflection that led to an interception in the second quarter vs. Vegas.

Pierce has now sat out two straight games due to a concussion. He was a full participant in two practices last week, but he sat out Friday and was ruled out against the Raiders.

Pierce's return has been highly anticipated, especially since he's a deep ball threat who can really open up Shane Steichen's offense.

Cardinals' Injury Report

• DL Darius Robinson (Pectoral) - DNP
• QB Kyler Murray (Foot) - DNP
• OL Kelvin Beachum (NIR-Rest) - DNP
• OL Evan Brown (Hamstring) - LP
• OL Will Hernandez (Knee) - LP
• CB Will Johnson (Groin) - LP
• WR Zay Jones (Knee) - LP
• CB Max Melton (Hamstring) - LP
• LB Cody Simon (Knee) - LP
• OL Jonah Williams (Foot) - LP
• LB Mack Wilson Sr. (Ankle) - LP

Wednesday's Injury Report ⤵️

— Arizona Cardinals (@AZCardinals) October 8, 2025

The first obvious name that sticks out is Murray, who sat out and is "day to day" according to head coach Jonathan Gannon. Arizona's backup quarterback is Jacoby Brissett.

Brown, Jones, and Williams are all offensive starters. They were all limited on Wednesday, which could indicate they'll be okay by Sunday.

Johnson and Melton make up the two outside starting corners for the Cardinals, but they were also limited.

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