Jaguars at 49ers: Week 4 Live Game Thread

The Jacksonville Jaguars have gotten off to an impressive 2-1 start to the 2025 NFL season, but they've yet to tally a true statement win this year. This is evidenced by the doubt still surrounding this team heading into its Week 4 clash with the San Francisco 49ers.

Jacksonville was able to open the campaign with a 26-10 domination of the Carolina Panthers. While the Jaguars' defense was excellent in that game, and the offense did more than enough to get the victory, beating down on a bottom-feeder at home isn't exactly proof that this team is ready to contend this year.

They followed that up with a disappointing loss on the road to the Cincinnati Bengals. In that one, they failed to capitalize on some key opportunities, including Joe Burrow's exit after three drives and three interceptions from backup quarterback Jake Browning. However, they bounced back with a divisional upset over the Houston Texans.

Jacksonville Jaguars, NFL, Houston Texans, Jarrian Jones, Jourdan Lewis — Jacksonville Jaguars cornerback Jourdan Lewis (2), second from right, is congratulated by cornerback Jarrian Jones (22), right, for his interception during the fourth quarter of an NFL football matchup at EverBank Stadium, Sunday, Sept. 21, 2025, in Jacksonville, Fla. The Jaguars defeated the Texans 17-10. | Corey Perrine/Florida Times-Union / USA TODAY NETWORK via Imagn Images

Jaguars need to prove themselves vs. 49ers

The Jacksonville Jaguars' latest win was a critical one for their chances to win the AFC South. It moved them to 2-1 on the year and 1-0 in the division, putting them in hot pursuit of the undefeated Indianapolis Colts. The Colts face a tough task in Week 4 trying to get a win on the road against the Los Angeles Rams.

This opens the door for Jacksonville to even the score with Indianapolis. Of course, that requires the Colts to lose and the Jaguars to get their first win away from EverBank Stadium under Head Coach Liam Coen. Like Indianapolis, Jacksonville is also matched up with a prospective title contender in Week 4, taking on the San Francisco 49ers.

Seattle Seahawks, NFL, San Francisco 49ers, Brock Purdy — Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers quarterback Brock Purdy (13) celebrates after throwing a touchdown pass against the Seattle Seahawks during the fourth quarter at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images | Joe Nicholson-Imagn Images

49ers are vulnerable

So far, the Niners have yet to lose a game this year. However, their wins haven't been all that impressive. This season, they've narrowly edged out the Seattle Seahawks in the opener, squeaked by a 0-3 New Orleans Saints team in Week 2, and needed a game-winning field goal to down the now 2-2 Arizona Cardinals.

San Francisco also comes into Week 4 with a huge disadvantage on the injury report. The Jaguars will be without linebacker Yasir Abdullah and offensive lineman Wyatt Milum, while Dyami Brown has a questionable tag.

However, the 49ers won't have Nick Bosa or Brandon Aiyuk. Brock Purdy hurried back from a turf toe injury to take over for Mac Jones, who aggravated a PCL sprain this week. Jauan Jennings, Ricky Pearsall, and Renardo Green are all questionable for San Fran, among others. Be sure to keep up with our updates on this live game thread.

Live Game Thread

BIG PLAY: Brock Purdy finds Kyle Jusczcyk wide open with room to run for an 18-yard pickup on the first offensive snap of the game for the San Francisco 49ers.

BIG PLAY: On 3rd-and-7, the Niners elect to give the rock to Christian McCaffrey, who gains 11 on a straight forward rush.

OPEN FIELD TACKLE: Travis Hunter gets a tackle on his first defensive snap of the game against former Jaguars tight end Luke Farrell.

BIG STOP: Jacksonville's pressure gets to Brock Purdy in the backfield, flushing him out right and forcing an uncatchable throw wide right of the end zone on 3rd-and-goal.

SCORING UPDATE NO. 1: Eddy Pineiro knocks in a 26-yard chip. JAX 0-3 SF

MENTAL ERROR: Rather than let the kickoff go out of bounds and put the Jaguars on their own 40-yard line, rookie LeQuint Allen Jr. fields it and crosses the sideline at the seven.

STARTING HOT: Brian Thomas Jr. notches his first catch just two plays in the game for Jacksonville's offense, bringing in a 14-yard out for a first-down conversion.

NEAR DISASTER: Trevor Lawrence tries to squeeze one into tight end Johnny Mundt. The ball is batted into the air and was nearly picked off by star linebacker Fred Warner.

FOURTH DOWN: On 4th-and-1 from San Francisco's 40, Liam Coen elects to go for it. Trevor Lawrence picks up the first down and some on a QB sneak.

BIG PLAY: Brian Thomas Jr. can't get both feet down on a near first-down pickup on 3rd-and-13. Logan Cooke's punt goes into the end zone, resulting in a touchback for the 49ers.

END OF 1ST QUARTER - JAX 0-3 SF

ROOKIE VS. ROOKIE: Ricky Pearsall picks up a first down on a short curl against Travis Hunter Jr. on 3rd-and-2 for San Francisco.

FUMBLE: Dennis Gardeck punches out the ball from Luke Farrell. Andrew Wingard falls on the ball to give the Jaguars the ball at San Franciso's 48-yard line.

SCORING UPDATE NO. 2: On the very next play, Travis Etienne Jr. takes it to the house on an outside run to the left. JAX 7-3 SF

STUFFED: Josh Hines-Allen sheds the blocker and brings down Christian McCaffrey in the backfield for a tackle for loss.

BIG PLAY: On 3rd-and-5, Purdy finds Ricky Pearsall who makes the catch from the ground despite a defensive pass interference from Jourdan Lewis for a 32-yard completion.

INTERCEPTION: Purdy's next pass bounces off his target, Christian McCaffrey, and Devin Lloyd winds up with the pick for Jacksonville's second takeaway of the game.

BIG PLAY: On 3rd-and-15 from their own six-yard line, Lawrence finds Travis Hunter Jr. over the middle for a contested catch for 28 yards and the first down.

CALL STANDS: SF Head Coach Kyle Shanahan elects to challenge the catch, but the refs rule in Jacksonville's favor. Niners are down to just one timeout with over 11 minutes left in the first half.

BIG PLAY: After taking a delay of game and a timeout to make sure they get the correct call on third down, Lawrence finds Brenton Strange in the middle of the field for eight yards.

SCORING UPDATE NO. 3: Lawrence finds Hunter Long for his second touchdown of the season on a play-action rollout to the left. JAX 14-3 SF

3-AND-OUT: Jacksonville's pass rush hurries Brock Purdy into an overthrow over the middle, and the 49ers go three and out on their first drive after the Jaguars go up by two scores.

BIG STOP: The Jaguars' drive stalls after Lawrence underthrows Brenton Strange on third down. Strange tips it, and Fred Warner lets a second potential interception fall in the dirt.

BIG PLAY: Facing another 3-and-out, Purdy finds Jake Tonges for a 14-yard gain on 3rd-and-10.

BIG PLAY: 49ers successfully run a hook-and-ladder lateral between Ricky Pearsall and Christian McCaffrey for a 23-yard pickup.

BIG STOP: Devin Lloyd chases Purdy out of the pocket who throws it away on 3rd-and-goal.

SCORING UPDATE NO. 4: San Francisco settles for a 23-yard field goal after a 12-play, 54-yard drive. JAX 14-6 SF

HUGE RETURN: Bhayshul Tuten brings San Francisco's kickoff back 54 yards to the 49ers' 47-yard line with 32 seconds left in the half.

SCORING UPDATE NO. 5: Taking advantage of Tuten's big return and a 15-yard facemask penalty from the Niners, the Jaguars get a Cam Little 26-yard chip shot to end the half. JAX 17-6 SF

END OF 2ND QUARTER - JAX 17-6 SF

3-AND-OUT: Jaguars can't capitalize on the first possession of the second half, going 3-and-out after a Travis Etienne Jr. run on 3rd-and-2 is stopped short of the line to gain.

BIG PLAY: Purdy finds Jake Tonges on a tight end seam for a 24-yard chunk.

BIG PLAY: Facing 3rd-and-6, Jauan Jennings pulls down a high throw over the middle for 14 yards.

BACK-TO-BACK: The Jaguars are called for a defensive pass interference and a defensive holding on two straight plays, putting the Niners on Jacksonville's 10-yard line. Jags now have nine accepted penalties on the day.

SCORING UPDATE NO. 6: Christian McCaffrey takes a shovel pass off a play-action fake into the house. 49ers two-point attempt is caught on a jump ball to Jauan Jennings. JAX 17-14 SF

SIGH OF RELIEF: On 3rd-and-15 facing their second 3-and-out of the half, Trevor Lawrence throws a would-be interception. Thankfully, he was drawing the attention of the referees to a defensive pass interference from the Niners. First down Jaguars.

BIG PLAY: On the next play, Etienne Jr. continues his strong day with a 18-yard burst on a pitch play.

BIG STOP: With the Jaguars driving, a Lawrence target to Parker Washington is batted down to force 4th-and-7 just into 49ers' territory. Jacksonville can't stop Cooke's punt short of the end zone, and San Francisco gets another touchback.

INTERCEPTION: Devin Lloyd gets his second interception of the day on the first play of the drive. He's the beneficiary of a tipped pass from Maason Smith.

ANOTHER SAVE: On 3rd-and-13, Lawrence finds Travis Hunter Jr. on a short curl, but Fred Warner punches the ball out. LeQuint Allen Jr. is able to fall on it to retain possession for Jacksonville.

SCORING UPDATE NO. 7: Cam Little converts on a 44-yard boot. JAX 20-14 SF

3-AND-OUT: Kendrick Bourne drops a wide open pass in the middle of Jacksonville's zone, forcing the Niners to punt on 4th-and-9.

SCORING UPDATE NO. 8: Parker Washington takes the punt 87 yards to the house. Lawrence's pass on the two-point conversion is tipped and flies through the back of the end zone. JAX 26-14 SF

BIG PLAY: Demarcus Robinson reels in a high pass over the middle for a 20-yard gain.

NEARLY A FOURTH: Foyesade Oluokun puts the ball in the dirt once again, punching it out after a short catch from Christian McCaffrey. 49ers fall on it to prevent their fourth turnover of the day.

END OF 3RD QUARTER - JAX 26-14 SF

BIG STOP: Devin Lloyd, among a pile, stops Christian McCaffrey near the line of scrimmage on 3rd-and-3.

TURNOVER ON DOWNS: Brock Purdy's 4th-down attempt sails over everybody, and the Jaguars take over at their own 26-yard line.

3-AND-OUT: Bhayshul Tuten sheds several defenders but can't convert on 3rd-and-1. Logan Cooke's punt bounces out of bounds just inside the Niners' 10-yard line.

BIG PLAY: Facing 3-and-out on 3rd-and-1, Christian McCaffery gets on the outside of the Jaguars' zone and picks up 29 yards on a catch and run.

BIG PLAY: On 3rd-and-5, Kendrick Bourne has sure hands on this one, completing a nice floater from Purdy in the second level of Jacksonville's zone.

SCORING UPDATE NO. 9: Jake Tonges continues his big day, taking a tight end screen 21 yards to the end zone. JAX 26-21 SF

SECOND EFFORT: On 3rd-and-1 looking at another 3-and-out, Trevor Lawrence is seemingly stuffed on a QB sneak, but a second surge brings him over the line to gain.

NO GOOD: Cam Little's 47-yard field goal is driven wide right by the wind, and San Francisco takes over at its own 29-yard line down five with 3:32 left in the contest.

FUMBLEROOSKI: Arik Armstead sneaks his hand into Brock Purdy's clutch on a six-man blitz and frees the ball. Foyesade Oluokun falls on it for the Jaguars' fourth takeaway of the game.

DAGGER: Lawrence finds Hunter Long on 3rd-and-5 for the conversion, and Jacksonville can run out the clock after the two-minute warning.

END OF 4TH QUARTER - JAX 26-21 SF

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