Week 4 Fantasy Football Defense Rankings: Buffalo At The Top Of The List

Michael Fabiano | Sep 25, 2025

Bills LB Matt Milano (58) and his defensive teammates have a plus home matchup against the Saints in Week 4. / Tina MacIntyre-Yee/Democrat and Chronicle / USA TODAY NETWORK via Imagn Images

The defensive rankings are always fluid, as there are few elite units and more fantasy fans are playing the weekly matchups.

The Bills are atop this week’s list, and teams like the Packers (Micah Parsons revenge game), Broncos, Texans, and Lions (among others) have plus matchups and are very startable assets.

On the flip side, big-name defenses like the Ravens and Chiefs have tough matchups (facing each other), and the Rams will be tough to trust with a home road matchup against the Colts. With that said, here are my fantasy defense rankings for Week 4.

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Week 4 Fantasy Defense Rankings

RK	Player	TM	Opponent
1	Bills	BUF	vs. NO
2	Broncos	DEN	vs. CIN
3	Texans	HOU	vs. TEN
4	Packers	GB	at DAL
5	Lions	DET	vs. CLE
6	Vikings	MIN	at PIT
7	Chargers	LAC	at NYG
8	Patriots	NE	vs. CAR
9	49ers	SF	vs. JAC
10	Eagles	PHI	at TB
11	Steelers	PIT	vs. MIN
12	Cardinals	ARI	vs. SEA
13	Rams	LAR	vs. IND
14	Commanders	WAS	at ATL
15	Jets	NYJ	at MIA
16	Raiders	LV	vs. CHI
17	Seahawks	SEA	at ARI
18	Titans	TEN	at HOU
19	Falcons	ATL	vs. WAS
20	Bears	CHI	at LV
21	Panthers	CAR	at NE
22	Dolphins	MIA	vs. NYJ
23	Jaguars	JAC	at SF
24	Colts	IND	at LAR
25	Bengals	CIN	at DEN
26	Chiefs	KC	vs. BAL
27	Ravens	BAL	at KC
28	Cowboys	DAL	vs. GB
29	Buccaneers	TB	vs. PHI
30	Giants	NYG	vs. LAC
31	Browns	CLE	at DET
32	Saints	NO	at BUF