Multiple 49ers Listed as Questionable for Week 18 Against the Seahawks

It's fantastic that the 49ers don't have a player ruled out against the Seahawks.

Dec 28, 2025; Santa Clara, California, USA; San Francisco 49ers wide receiver Ricky Pearsall (1) and linebacker Luke Gifford (57) talk before the game against the Chicago Bears at Levi's Stadium. Mandatory Credit: Sergio Estrada-Imagn Images | Sergio Estrada-Imagn Images

All hands on deck are needed for the San Francisco 49ers if they want to beat the Seattle Seahawks on Saturday night.

Surprisingly, they have a chance to achieve that. Kyle Shanahan revealed on Thursday that no player has been ruled out ahead of their critical Week 18 matchup, but there are five 49ers listed as questionable.

Trent Williams

Oct 19, 2025; Santa Clara, California, USA; San Francisco 49ers offensive tackle Trent Williams (71) blocks against Atlanta Falcons defensive end James Pearce Jr. (27) during the second quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images | Darren Yamashita-Imagn Images

As encouraging as it is to see that Trent Williams is listed as questionable, he's most likely not going to play on Saturday night. He hasn't practiced all week due to a hamstring injury.

He sustained it on the first play of the game on Sunday night against the Chicago Bears. Hamstrings usually don't recover in six days, so Williams will be playing hurt if he suits up.

I just wouldn't expect him to do so. Austen Pleasants will get the nod to fill in for Williams again if he's ruled out.

George Kittle

Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers tight end George Kittle (85) reacts during the third quarter against the Tennessee Titans at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images | Cary Edmondson-Imagn Images

A true encouraging sign is that George Kittle is recovering from his ankle sprain. Although he's also likely going to be playing through pain.

But this isn't a game he's going to miss out on. It's not like a hamstring injury that totally restricts a player. Kittle can brace and tape up his ankle to reduce the pain.

Plus, he's already made it clear that he's going to play against Seattle. Being without Kittle and Williams would be devastating for the 49ers. Thankfully, they will have Kittle available.

Ricky Pearsall

Dec 28, 2025; Santa Clara, California, USA; San Francisco 49ers wide receiver Ricky Pearsall (1) celebrates in the first half against the Chicago Bears at Levi's Stadium. Mandatory Credit: Sergio Estrada-Imagn Images | Sergio Estrada-Imagn Images

The PCL sprain will be an ongoing issue for Ricky Pearsall until the season ends. He will end up being indefinitely listed as questionable from here on out.

There should be no concern for him to miss this game. He quietly had a solid performance against the Bears, putting up five catches for a team-high 85 yards.

Upton Stout

Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers cornerback Upton Stout (20) reacts during the third quarter against the Tennessee Titans at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images | Cary Edmondson-Imagn Images

A concussion took rookie Upton Stout out of the game against Chicago. He's still currently in the concussion protocol, but his progression in practice is massively positive.

Stout managed to shed the blue no-contact jersey on the final day of practice on Thursday. There's a good chance he will suit up against the Seahawks.

Keion White

Nov 30, 2025; Cleveland, Ohio, USA; San Francisco 49ers defensive end Keion White (56) and San Francisco 49ers defensive end Clelin Ferrell (96) sack Cleveland Browns quarterback Shedeur Sanders (12) during the second half at Huntington Bank Field. Mandatory Credit: Ken Blaze-Imagn Images | Ken Blaze-Imagn Images

Another player who couldn't finish the game against the Bears is Keion White. A groin injury took him out of the game and for two practices this week.

However, he was able to practice in the final session on a limited basis. That gives him a shot to suit up and play against Seattle. The 49ers can ill-afford being down a defensive lineman.

Follow Jose on X (Twitter) @JS3sanchezz to interact with him and subscribe to his YouTube Channel here for more 49ers content

---