After loss to Patriots, Bills no longer perfect but remain Super Bowl LX favorites

Looking for something positive to pour in your glass-half-full optimism on a mopey Monday, Bills Mafia? After Sunday night's loss the Buffalo Bills' odds to win Super Bowl LX went up.

Meaning? More bang for your buck when they win their first championship come February in Santa Clara.

MORE: Josh Allen disgusted by Bills' 'piss-poor' performance in upset loss to Patriots

Despite the disappointing, upset loss to the New England Patriots in a "white out" primetime game on Sunday Night Football, the sky is hardly falling over Orchard Park. They uncharacteristically committed three turnovers, but it still took a 52-yard field goal in the final seconds to beat them.

Despite their flaws — and the fact that they will not go 17-0 — the Bills remain strong favorites to win the AFC East, the AFC and Super Bowl LX. Their odds increased slightly in the wake of the loss, from +450 to +490. So now a $100 bet on the Bills to win it all will return $490 instead of $450.

Buffalo Bills quarterback Josh Allen rallies the offense as play starts in the final seconds of the fourth quarter at Highmark Stadium in Orchard Park on Oct. 5, 2025. The Bills could not rally to win. | Tina MacIntyre-Yee/Democrat and Chronicle / USA TODAY NETWORK via Imagn Images

The Philadelphia Eagles, who also feels from the ranks of the unbeaten Sunday, retain the second-best odds at +750, followed by the surging Detroit Lions at +800 and Kansas City Chiefs at +850.

MORE: Stunning drone footage shows Highmark Stadium construction ahead of Bills-Patriots

Sunday was a weird day. Maybe it's because of Monday night's SuperMoon. Regardless, it was the first day in NFL history that two 4-0 teams lost. Now the NFL has no undefeated teams through five weeks for the first time since 2014.

Bottom line: the Bills aren't perfect, but they're still the team to beat in the AFC.

Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

Patriots quarterback Drake Maye feels the pressure from Bills defensive end Greg Rousseau in Week 5. | Tina MacIntyre-Yee/Democrat and Chronicle / USA TODAY NETWORK via Imagn Images

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