5 Bold Predictions For the Rams-49ers Rematch

The Los Angeles Rams look to defeat their hated rivals from the North

Nov 2, 2025; Inglewood, California, USA; Los Angeles Rams quarterback Matthew Stafford (9) stands in the pocket against the New Orleans Saints during the first half at SoFi Stadium. Mandatory Credit: Kiyoshi Mio-Imagn Images | Kiyoshi Mio-Imagn Images

WOODLAND HILLS, Ca. The Los Angeles Rams are ready to play the San Francisco 49ers in a rematch of their week five overtime defeat. Taking on their arch rivals in enemy territory, Sean McVay looks to pick up a third straight win at Levi Stadium, something that he's never done in his head coaching career.

With the stage set, here are my predictions for Sunday's contest.

1. Matthew Stafford is vintage

Stafford has been playing out of his mind in 2025, taking his solid performance against the 49ers in week five, pairing it with the irritation from such a loss and a new offensive approach from Sean McVay to put in three straight weeks of surgical efficiency.

Nov 2, 2025; Inglewood, California, USA; Los Angeles Rams quarterback Matthew Stafford (9) stands in the pocket against the New Orleans Saints during the first half at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images | Jayne Kamin-Oncea-Imagn Images

While the passing yards will fluctuate in volume, the red zone improvements are evident. Stafford has at least three passing touchdowns and over 250 yards passing.

2. Davante Adams enacts his revenge

Adams has an odd relationship with the 49ers, stemming from his upbringing in Northern California and then expounded upon from his stints with the Packers and Raiders. Even failed negotiations this offseason factor into it, though what exactly happens from that situation remains unclear.

Nov 2, 2025; Inglewood, California, USA; Los Angeles Rams wide receiver Davante Adams (17) low fives wide receiver Xavier Smith (19) after catching a touchdown against the New Orleans Saints during the first half at SoFi Stadium. Mandatory Credit: Kiyoshi Mio-Imagn Images | Kiyoshi Mio-Imagn Images

Adams was asked if he's a 49ers fan and said this.

“Similar to how I feel about them now, never really liked them," stated Adams earlier in the week. "Naturally going back to the Packers, that was kind of like our rival other than the Bears, but we didn't really look at that like much of a rivalry game. All jokes aside, they’re a team that since I’ve been in the league they’ve been in our way."

Nov 2, 2025; Inglewood, California, USA; Los Angeles Rams wide receiver Davante Adams (17) runs after the catch as New Orleans Saints safety Justin Reid (21) attempts to make the tackle during the second half at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images | Jayne Kamin-Oncea-Imagn Images

"With the Packers, they beat us a few times in some pretty meaningful games. It always brings out a little bit more inside of you. Going back home and being in front of the home crowd it’s always been fun to play those games in front of my family and some people from high school. It’s a meaningful one.”

Due to the extra juice, Adams has at least six catches for 80 yards and two touchdowns.

3. Kyren Williams picks up the dirty yards

Nov 2, 2025; Inglewood, California, USA; Los Angeles Rams running back Kyren Williams (23) carries the ball as New Orleans Saints cornerback Alontae Taylor (1) defends during the first half at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images | Jayne Kamin-Oncea-Imagn Images

Williams' use in the pass game in week five opened up the end zone for the Rams and if not for a critical fumble, his work would've made him the game's MVP. Football is a game of inches and moments, with Williams again finding his on Sunday. Williams has at least 100 total yards and one score.

4. Emmanuel Forbes does it again

Oct 2, 2025; Inglewood, California, USA; San Francisco 49ers running back Christian McCaffrey (23) rushes the ball past Los Angeles Rams cornerback Emmanuel Forbes Jr. (1) during the second half at SoFi Stadium. Mandatory Credit: Kirby Lee-Imagn Images | Kirby Lee-Imagn Images

After securing his first interception with the franchise last week, Forbes will get the snaps, safety help, and opportunities to jump a pass. He secures his second on Sunday and another highlight tackle.

5. Byron Young returns to his premium production

Sep 21, 2025; Philadelphia, Pennsylvania, USA; Los Angeles Rams linebacker Byron Young (0) against the Philadelphia Eagles at Lincoln Financial Field. Mandatory Credit: Eric Hartline-Imagn Images | Eric Hartline-Imagn Images

Young was arguably robbed last week of continuing his streak of consecutive games with a recorded sack after his takedown of Tyler Shough was ruled a penalty due to the physicality behind his hit. With a new target angle and fire in his belly, Young records two sacks on Sunday.

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