Week 10 Fantasy Football Defense Rankings: Bills DST In The Top Five

Michael Fabiano | Nov 6, 2025

The Buffalo Bills defense faces the Miami Dolphins in Week 10. / Tina MacIntyre-Yee/Democrat and Chronicle / USA TODAY NETWORK via Imagn Images

Welcome to Week 10!

The NFL continues with a four-team bye this week with the Bengals, Chiefs, Cowboys and Titans all off. That obviously takes all four of their defenses off the board.

This week also marks the return of the league’s international series, as the Atlanta Falcons and Indianapolis Colts will battle it out in Berlin, Germany. The game will start at 9:30 a.m. on the east coast, so you’ll want to set your fantasy lineups in advance.

This week’s DST risers include Broncos, Bills, and Panthers defenses, all of whom have great matchups next on the schedule. On the flip side, defenses like the Eagles, Packers, and Chargers could struggle versus tougher foes.

With that said, here are my complete fantasy football defense rankings for Week 10 of the NFL season.

Be sure to check back all week for daily updates!

All Positions: QBs | RBs | WRs | TEs | FLEX | Ks

Week 10 Fantasy DST Rankings

RK	Player	TM	Opponent
1	Broncos	DEN	vs. LV
2	Bills	BUF	at MIA
3	Lions	DET	at WAS
4	Browns	CLE	at NYJ
5	Panthers	CAR	vs. NO
6	Seahawks	SEA	vs. ARI
7	Jaguars	JAC	at HOU
8	Jets	NYJ	vs. CLE
9	Rams	LAR	at SF
10	Colts	IND	vs. ATL
11	Ravens	BAL	at MIN
12	Texans	HOU	vs. JAC
13	Buccaneers	TB	vs. NE
14	Bears	CHI	vs. NYG
15	Patriots	NE	at TB
16	Chargers	LAC	vs. PIT
17	Packers	GB	vs. PHI
18	Giants	NYG	at CHI
19	Steelers	PIT	at LAC
20	Eagles	PHI	at GB
21	Saints	NO	at CAR
22	Vikings	MIN	vs. BAL
23	Cardinals	ARI	at SEA
24	Falcons	ATL	at IND
25	Commanders	WAS	vs. DET
26	49ers	SF	vs. LAR
27	Raiders	LV	at DEN
28	Dolphins	MIA	vs. BUF