Week 6 Fantasy Football Defense Rankings: Pittsburgh At The Top Of The List

Michael Fabiano | Oct 10, 2025

Steelers superstar T.J. Watt and his defensive teammates have a plus matchup against the Cleveland Browns in Week 6. / Charles LeClaire-Imagn Images

The fifth week of the NFL season has come and gone, and we’ve already entered the bye weeks. The good news is that only two teams, the Houston Texans and Minnesota Vikings, are off the board. There is also another international game, as the Denver Broncos face the New York Jets in London (9:30 a.m. ET).

The Week 6 rankings are led by some of the usual defensive suspects, as the Steelers, Eagles, Packers and Broncos are all in the top 10. The Rams have a plus matchup against the Ravens, who’ll be without Lamar Jackson, and the Patriots and Raiders are both nice streamers based on their matchups.

With that said, here are my complete fantasy football defense rankings for the sixth week of the NFL season.

All Positions: QBs | RBs | WRs | TEs | FLEX | Ks

Week 6 Fantasy DST Rankings

RK	Player	TM	Opponent
1	Steelers	PIT	vs. CLE
2	Eagles	PHI	at NYG
3	Packers	GB	vs. CIN
4	Broncos	DEN	at NYJ
5	Rams	LAR	at BAL
6	Raiders	LV	vs. TEN
7	Buccaneers	TB	vs. SF
8	Patriots	NE	at NO
9	Browns	CLE	at PIT
10	Chargers	LAC	at MIA
11	Colts	IND	vs. ARI
12	Titans	TEN	at LV
13	Commanders	WAS	vs. CHI
14	Seahawks	SEA	at JAC
15	Cowboys	DAL	at CAR
16	Jaguars	JAC	vs. SEA
17	Bills	BUF	at ATL
18	Saints	NO	vs. NE
19	49ers	SF	at TB
20	Ravens	BAL	vs. LAR
21	Jets	NYJ	vs. DEN
22	Dolphins	MIA	vs. LAC
23	Lions	DET	at KC
24	Chiefs	KC	vs. DET
25	Cardinals	ARI	at IND
26	Bears	CHI	at WAS
27	Giants	NYG	vs. PHI
28	Panthers	CAR	vs. DAL
29	Bengals	CIN	vat GB
30	Falcons	ATL	vs. BUF
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