Carolina Panthers early Week 4 odds vs. New England Patriots revealed

The Carolina Panthers will travel to Foxborough for a Week 4 showdown against the Patriots on Sunday.

Sep 21, 2025; Charlotte, North Carolina, USA; Carolina Panthers quarterback Bryce Young (9) runs in the first quarter at Bank of America Stadium. | Bob Donnan-Imagn Images

Despite notching the first win of the season in the home opener on Sunday, the Carolina Panthers open Week 4 as 3.5-point underdogs against the New England Patriots. The Las Vegas odds across the board have the Panthers as the underdogs for Week 4.

The Panthers must once again hit the road after enjoying an "electric" home field advantage on Sunday as they blanked the Atlanta Falcons 30-0.

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Sep 21, 2025; Charlotte, North Carolina, USA; Carolina Panthers quarterback Bryce Young (9) and Atlanta Falcons free safety Jessie Bates (3) embrace following the game at Bank of America Stadium. | Cory Knowlton-Imagn Images

Carolina is 0-2 so far in road games this season. They lost the season opener against the Jacksonville Jaguars 26-10, but had a better performance against the Arizona Cardinals on the road in Week 2. They fell 27-22 in that outing.

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Since the Vegas odds for Week 4 came out, the Panthers have since boosted their underdog status with lines going from 3.5 points to 5.5. Mike Vrabel's first year Patriots squad is coming off a 21-14 loss to the Pittsburgh Steelers. Their one win on the year so far came in Week 2, 33-27 against the struggling Miami Dolphins.

The moneyline for Sunday's Week 4 matchup between the Carolina Panthers and New England Patriots is +190 for Carolina and -230 for New England, according to FanDuel. The total for the game is set at 44.5 points.

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