NFL Week 1 Opening Odds for Every Game (Bills Favored vs. Ravens on Sunday Night Football)

Iain MacMillan | May 14, 2025

The Bills are 1.5-point favorites against the Ravens on Sunday Night Football in Week 1 of the 2025 NFL regular season. / Tina MacIntyre-Yee/Democrat and Chronicle / USA TODAY NETWORK via Imagn Images

The NFL schedule has officially been released!

Now, we have the next four months to examine it and imagine how our teams will fare this upcoming season. Not only that, but sportsbooks have released the betting odds for a plethora of games, including every single Week 1 matchup.

Curious if your team is favored to start the 2025 campaign 1-0? Let's find out.

2025 NFL Week 1 Odds

All odds below via DraftKings Sportsbook

Cowboys vs. Eagles Opening Odds

Spread

• Cowboys +7 (-110)
• Eagles -7 (-110)

Moneyline

• Cowboys +250
• Eagles -310

Total

• 46.5 (Over -110/Under -110)

Chiefs vs. Chargers Opening Odds

Spread

• Chiefs -3 (-110)
• Chargers +3 (-110)

Moneyline

• Chiefs -155
• Chargers +130

Total

• 44.5 (Over -110/Under -110)

Cardinals vs. Saints Opening Odds

Spread

• Cardinals -3.5 (-115)
• Saints +3.5 (-105)

Moneyline

• Cardinals -192
• Saints +160

Total

• 43.5 (Over -115/Under -105)

Bengals vs. Browns Opening Odds

Spread

• Bengals -4.5 (-118)
• Browns +4.5 (-102)

Moneyline

• Bengals -205
• Browns +170

Total

• 44.5 (Over -110/Under -110)

Dolphins vs. Colts Opening Odds

Spread

• Dolphins +1.5 (-112)
• Colts -1.5 (-108)

Moneyline

• Dolphins +100
• Colts -120

Total

• 45.5 (Over -110/Under -110)

Raiders vs. Patriots Opening Odds

Spread

• Raiders +3.5 (-115)
• Patriots -3.5 (-105)

Moneyline

• Raiders +140
• Patriots -166

Total

• 43.5 (Over -110/Under -110)

Giants vs. Commanders Opening Odds

Spread

• Giants +7.5 (-110)
• Commanders -7.5 (-110)

Moneyline

• Giants +270
• Commanders -340

Total

• 45.5 (Over -105/Under -115)

Buccaneers vs. Falcons Opening Odds

Spread

• Buccaneers -2.5 (-115)
• Falcons +2.5 (-105)

Moneyline

• Buccaneers -142
• Falcons +120

Total

• 47.5 (Over -110/Under -110)

Panthers vs. Jaguars Opening Odds

Spread

• Panthers +3.5 (-115)
• Jaguars -3.5 (-105)

Moneyline

• Panthers +140
• Jaguars -166

Total

• 45.5 (Over -115/Under -105)

Steelers vs. Jets Opening Odds

Spread

• Steelers -2.5 (-110)
• Jets +2.5 (-110)

Moneyline

• Steelers -130
• Jets +110

Total

• 41.5 (Over +100/Under -120)

Texans vs. Rams Opening Odds

Spread

• Texams +3.5 (-110)
• Rams -3.5 (-110)

Moneyline

• Texans +145
• Rams -175

Total

• 44.5 (Over -110/Under -110)

49ers vs. Seahawks Opening Odds

Spread

• 49ers -1.5 (-108)
• Seahawks +1.5 (-112)

Moneyline

• 49ers -120
• Seahawks +100

Total

• 45.5 (Over -110/Under -110)

Titans vs. Broncos Opening Odds

Spread

• Titans +7.5 (-108)
• Broncos -7.5 (-115)

Moneyline

• Titans +295
• Broncos -375

Total

• 43.5 (Over -110/Under -110)

Lions vs. Packers Opening Odds

Spread

• Lions +1.5 (-112)
• Packers -1.5 (-108)

Moneyline

• Lions +102
• Packers -118

Total

• 47.5 (Over -110/Under -110)

Ravens vs. Bills Opening Odds

Spread

• Ravens +1.5 (-110)
• Bills -1.5 (-110)

Moneyline

• Ravens +102
• Bills -122

Total

• 51.5 (Over -110/Under -110)

Vikings vs. Bears Opening Odds

Spread

• Vikings +1.5 (-110)
• Bears -1.5 (-110)

Moneyline

• Vikings +102
• Bears -122

Total

• 45.5 (Over -105/Under -115)

---

Are you new to DraftKings? Sign up today and place a $5 bet to earn a guaranteed $200 in bonus bets. Win or lose, DraftKings will issue six $25 bonus bets instantly.

Odds refresh periodically and are subject to change.

If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.