Omarion Hampton injury update: Buzz, fantasy football outlook on Chargers star

Los Angeles Chargers first-round running back Omarion Hampton enjoyed a breakout while taking over for the injured Najee Harris, then he suffered a setback that sent him to injured reserve, too.

In the wake of the NFL trade deadline and as the Chargers approach the Week 10 game against the Pittsburgh Steelers, head coach Jim Harbaugh and some of those around the team hinted at the status of Hampton’s recovery timeline.

Here’s the latest on Hampton’s injury.

Omarion Hampton injury update

Speaking with reporters before Week 10, Harbaugh revealed that the Chargers will not open Hampton’s 21-day return window.
Hampton has not played since suffering an ankle injury during the October 5 loss to the Washington Commanders. He went to injured reserve during the next week’s roster moves.

When will Omarion Hampton return?

The Chargers not so much as opening Hampton’s return window effectively rules him out for the Week 11 game against the Jacksonville Jaguars, too. After that, it’s a Week 12 bye. Tacking on yet another three weeks to the injury speaks to just how severe it was. There’s no guarantee Hampton is back after the bye, either, though they could activate him during the buildup to Week 13 before putting him on the 53 for that week’s game against the Las Vegas Raiders.

Omarion Hampton fantasy football outlook

Omarion Hampton’s on pace for over 1,600 yards and 9 TD’s..

He would’ve been the CLEAR RB1 in 95%+ of draft classes

Chargers GM (Joe Hortiz) mentioned it was a “unanimous” decision between their Front Office to draft Hampton..

1st in Scrimmage Yards by a Rookie through 4 weeks pic.twitter.com/zrcE58mtsS
— Austin Abbott (@AustinAbbottFF) October 4, 2025

Bleak. Three more weeks without a capable first-rounder is a tough ask for fantasy footballers. That said, those who already have him on a roster or those who can buy really low might be in for a nice surge. Hampton will, presumably, come back on fresh legs and ready to go for the winter playoff stretch and there is literally zero competition for his snaps in the Chargers backfield when he does.

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