Cowboys vs Eagles Week 1 odds for 2025 opener: Dallas is heavy underdog

Dallas Cowboys Nation, we've officially made it to game week. It's been a chaotic few days with the roster gymnastics and reshuffling going on, including the Micah Parsons trade to the Green Bay Packers, which sent shockwaves through the NFL.

The Cowboys take the field in just a matter of days, traveling to Lincoln Financial Field to face the Super Bowl champion Philadelphia Eagles.

Because Dallas is taking the field after ditching its best player, the oddsmakers aren't feeling too good about the Cowboys' chances.

MORE: Eagles star breathes 'sigh of relief' facing Cowboys after Micah Parsons trade

In fact, the Cowboys are more than a one touchdown underdog.

Dallas Cowboys quarterback Dak Prescott throws a pass in the first quarter against the Philadelphia Eagles at AT&T Stadium. | Tim Heitman-Imagn Images

According to ESPN BET, the Eagles are significant 7.5-point favorites over the visiting Cowboys, while the over/under is just 47.5 total points.

The moneyline has Dallas as a +300 dog, while Philly is a -400 favorite.

That means a $100 wager on the Cowboys would land you a $300 profit, while you would have to risk $400 for a $100 payday by betting on the Eagles.

A full look at the betting odds and information for Thursday night's game can be seen below.

Dallas Cowboys at Philadelphia Eagles, Week 1 betting odds & viewing info

Dallas Cowboys quarterback Dak Prescott against the Philadelphia Eagles at Lincoln Financial Field. | Eric Hartline-Imagn Images

Date: Thursday, September 4, 2025
Start Time: 8:20 p.m. ET
Location: Philadelphia, Pennsylvania
Venue: Lincoln Financial Field
TV Info: NBC
Live Stream: Peacock

Betting Odds: Eagles -7.5 | O/U: 47.5 (odds via ESPN BET)
Moneyline: Eagles -400, Cowboys +300

Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

— Enjoy free coverage of the Cowboys from Dallas Cowboys on SI —

Micah Parsons FaceTimes viral young Cowboys fan heartbroken over trade to apologize

Jerry Jones' salary cap failures led to Micah Parsons trade, NFL announcer says

Dallas Cowboys, All-Pro cornerback DaRon Bland agree to massive contract extension before Week 1

Eagles name starting CBs, give Cowboys WRs opportunity to feast in Week 1

Jerry Jones doubles down on 'stopping run' narrative for Cowboys' Micah Parsons trade

PHOTOS: Meet Kleine Powell, star of Dallas Cowboys Cheerleader Netflix doc