San Francisco 49ers News - Sports Illustrated

ON SI
SI SWIMSUIT
SI NEWSLETTERS
SI TICKETS
SI RESORTS
SI SHOPS
MY ACCOUNT
SUBSCRIBE NOW

CFP
NFL
NBA
MLB
COLLEGE FOOTBALL
SOCCER
FANTASY
GOLF
MEDIA
BETTING

Home
OnSI
Schedule
Roster
Stats
Depth Chart
Tickets

San Francisco 49ers tight end George Kittle is a great prop target on Monday.

Best NFL Picks and Predictions Today (How to Bet 49ers vs. Colts on Monday Night Football in NFL Week 16)

Peter Dewey

|

22 Minutes Ago

How Elaborate NFL Gift Giving Became an Arms Race

Greg Bishop

|

24 Minutes Ago

Highly paid quarterbacks such as Joe Burrow are now expected to give teammates expensive gifts. But how does it really work?

The 20 Unwritten Rules of NFL Gift Giving

Greg Bishop

|

24 Minutes Ago

San Francisco 49ers running back Christian McCaffrey is a great prop target in Week 16.

49ers vs. Colts Best Anytime Touchdown Scorer Picks for Monday Night Football in NFL Week 16

Peter Dewey

|

37 Minutes Ago

Schedule

Standings

Team Leaders

Full Team Statistics

Injuries

Indianapolis Colts running back Jonathan Taylor is a great prop target in Week 16.

49ers vs. Colts Best NFL Prop Bets for Monday Night Football in Week 16 (Bet on Jonathan Taylor)

Peter Dewey

|

1 Hour Ago

The San Francisco 49ers and quarterback Brock Purdy are favored on Monday.

49ers vs. Colts Final Score Prediction for NFL Week 16 (Can 49ers Cover on Road?)

Peter Dewey

|

2 Hours Ago

Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers quarterback Mac Jones (10) warms up in the second half against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images

Why the 49ers Can’t Afford to Lose Mac Jones in 2026

Henry Cheal

|

9 Hours Ago

Robert Saleh reveals the secret ingredient for the 49ers defense

Parker Hurley

|

19 Hours Ago

Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers defensive coordinator Robert Saleh looks on in the third quarter against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images

49ers must fix this issue in final three games to secure No. 1 Seed

Henry Cheal

|

21 Hours Ago

One must-start in fantasy football on the San Francisco 49ers

Parker Hurley

|

Dec 21, 2025

Brandon Aiyuk posts alarming video speeding past 49ers facility

Grant Cohn

|

Dec 20, 2025

Nov 30, 2025; Cleveland, Ohio, USA; The San Francisco 49ers huddle up after the break during the second half against the Cleveland Browns at Huntington Bank Field. Mandatory Credit: Scott Galvin-Imagn Images

49ers Will be Without Two Skilled Starters Against Indianapolis

Jose Sanchez

|

Dec 20, 2025

Sep 14, 2025; Indianapolis, Indiana, USA; Indianapolis Colts defensive tackle DeForest Buckner (99) celebrates a tackle against Denver Broncos quarterback Bo Nix (10) during the fourth quarter at Lucas Oil Stadium. Mandatory Credit: Robert Goddin-Imagn Images

49ers Make it Clear How They Feel About DeForest Buckner

Jose Sanchez

|

Dec 20, 2025

Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers general manager John Lynch, right, talks with head coach Kyle Shanahan during pregame warmups against the Seattle Seahawks at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

49ers Put an End to This Rookie's Season

Jose Sanchez

|

Dec 20, 2025

August 23, 2025; Santa Clara, California, USA; San Francisco 49ers defensive coordinator Robert Saleh before the game against the Los Angeles Chargers at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images

Robert Saleh Gives Surprising Comments on the 49ers’ Run Defense

Jose Sanchez

|

Dec 20, 2025

Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) runs with the ball during the first quarter against the Tennessee Titans at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

Brock Purdy Sounds Off on the Colts’ Defense

Jose Sanchez

|

Dec 20, 2025

Colts defensive tackle DeForest Buckner is set to return to the lineup on Monday night.

Colts Receive Good News on DT DeForest Buckner Ahead of Monday’s Game vs. Niners

Mike McDaniel

|

Dec 20, 2025

Eric Saubert

Seahawks Week 16 rooting guide: is clinching NFC No. 1 seed on the table?

Richie Whitt

|

Dec 20, 2025

Nov 30, 2025; Cleveland, Ohio, USA; Cleveland Browns running back Dylan Sampson (22) runs the ball during the second half against the San Francisco 49ers at Huntington Bank Field. Mandatory Credit: Ken Blaze-Imagn Images

What the Biggest Challenge Will be for the 49ers Against Indianapolis

Jose Sanchez

|

Dec 20, 2025

Takedown Policy

Terms and Conditions

SI Accessibility Statement

© 2025 ABG-SI LLC - SPORTS ILLUSTRATED IS A REGISTERED TRADEMARK OF ABG-SI LLC. - All Rights Reserved. The content on this site is for entertainment and educational purposes only. Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Sports Illustrated or its affiliates, licensees and related brands. All picks and predictions are suggestions only and not a guarantee of success or profit. If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER.