James Cook clarifies injury status ahead of Buffalo Bills' Week 10 matchup vs. Dolphins

The Buffalo Bills' RB sustained an ankle injury during a Week 9 win over the Kansas City Chiefs and did not practice on Wednesday.

Oct 26, 2025; Charlotte, North Carolina, USA; Buffalo Bills running back James Cook III (4) scores a touchdown during the second half against the Carolina Panthers at Bank of America Stadium. | Jim Dedmon-Imagn Images

Finally, some good news on the Buffalo Bills’ injury front.

After missing practice on Wednesday and returning in a limited fashion on Thursday, James Cook provided clarity on his injury status leading into a Week 10 matchup with the Miami Dolphins.

RELATED: James Cook sustains apparent injury in first half of Week 9 matchup vs. Chiefs

James Cook is ALL SYSTEMS GO against Miami this week!

Bills fans rejoice! @UpAndAdamsShow pic.twitter.com/N1m2n6ayZi

— Kay Adams (@heykayadams) November 6, 2025

Cook sustained an ankle injury during the Bills’ Week 9 victory over the Kansas City Chiefs, but went on to finish the game while recording a massive workload of 27 carries for 114 yards rushing. And after dealing with some lingering effects from his game-day ailment to begin the week, it appears all is well for the Buffalo running back moving forward.

“I’m ready to go,” said Cook on Up & Adams with Kay Adams on Thursday. “I’m gonna be out there when it’s time to play on Sunday. (I’m) going back home. Gotta play at home.”

MORE: Joey Bosa, James Cook, several others injured, do not practice for Buffalo Bills

Buffalo Bills running back James Cook III has a wide open are to run the ball during first half action against the Kansas City Chiefs at Highmark Stadium in Orchard Park on Nov. 2, 2025. | Tina MacIntyre-Yee/Democrat and Chronicle / USA TODAY NETWORK via Imagn Images

Cook, a Miami native, is on pace for a career season, having recorded 867 yards rushing and seven rushing touchdowns over his first eight games of the season. His current career-high in yards rushing is 1,122, a mark he set during the 2023 season.

The Bills will take on a Dolphins’ rushing defense that has allowed 145.6 yards per game on the ground, which is the third most in the NFL. Cook previously recorded 108 yards rushing and a touchdown on 19 carries during the Bills’ win over Miami in Week 3.

Buffalo (6-2) is currently trailing the New England Patriots (7-2) in the AFC East standings and is in significant need of a win over the Dolphins to keep up with the Patriots, who previously beat the Bills in Week 5.

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