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The Colts are +240 underdogs to the 49ers in Week 16.

NFL Upset Predictions and Picks for Week 16 (Can Philip Rivers Lead Colts to Upset Win Over 49ers?)

Iain MacMillan

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33 Minutes Ago

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts quarterback Philip Rivers (17) passes against the Seattle Seahawks during the fourth quarter at Lumen Field.

Colts 'Have All the Confidence' in Philip Rivers

Sean Ackerman

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11 Hours Ago

Oct 26, 2025; Indianapolis, Indiana, USA; Indianapolis Colts running back Jonathan Taylor (28) celebrates after scoring a touchdown during the third quarter against the Tennessee Titans at Lucas Oil Stadium.

Jonathan Taylor, More Running Backs Reign Supreme in 2026 Fantasy Football Mock Draft

Ryan Shea

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13 Hours Ago

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts quarterback Philip Rivers (17) walks to the locker room following a loss against the Seattle Seahawks at Lumen Field.

Why Colts' Offense is Doomed With Philip Rivers

Sean Ackerman

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14 Hours Ago

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Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts quarterback Philip Rivers (17) walks to the locker room following the second quarter against the Seattle Seahawks at Lumen Field. Mandatory Credit: Kevin Ng-Imagn Images

Philip Rivers Suddenly Surfaces as Candidate for Illustrious NFL Honor

Drake Wally

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16 Hours Ago

The Dolphins fell to 6–8 after a loss to the Steelers and will miss the postseason.

Is the Tua Tagovailoa–Mike McDaniel Era Over in Miami?

Albert Breer

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17 Hours Ago

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts quarterback Philip Rivers (17) walks to the huddle during the first quarter against the Seattle Seahawks at Lumen Field.

Colts' Updated Path to Playoffs After Week 15

Sean Ackerman

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19 Hours Ago

Philip Rivers will make his second start of the season against the 49ers.

49ers vs. Colts Prediction, Odds, Spread, Injuries, Trends for NFL Week 16

Iain MacMillan

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20 Hours Ago

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts quarterback Philip Rivers (17) walks to the locker room following the second quarter against the Seattle Seahawks at Lumen Field. Mandatory Credit: Kevin Ng-Imagn Images

Philip Rivers Has Made Colts More Threatening After Difficult Loss

Drake Wally

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23 Hours Ago

Patriots running back TreVeyon Henderson has dominated the second half of the season.

SI’s Top-10-Ranked Rookies Include a Pair of RBs Headed for the NFL Playoffs

Matt Verderame

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Dec 17, 2025

Alabama quarterback Ty Simpson could be the pick for the Steelers in the first round of the 2026 NFL draft.

2026 NFL Mock Draft 4.0: Steelers Select Aaron Rodgers’s Replacement

Daniel Flick

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Dec 17, 2025

Nov 4, 2023; Ann Arbor, Michigan, USA; Michigan Wolverines offensive lineman LaDarius Henderson (73) gets set on offense at Michigan Stadium.

Colts Sign Trio of Offensive Linemen

Sean Ackerman

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Dec 16, 2025

Indianapolis Colts quarterback Anthony Richardson (5) throws a pass Sunday, Oct. 5, 2025, during a game against the Las Vegas Raiders at Lucas Oil Stadium in Indianapolis. The Colts defeated the Raiders 40-6.

Anthony Richardson Injury Update: Colts QB Receives Positive Update While On IR

Ethen Hutton

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Dec 16, 2025

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts quarterback Philip Rivers (17) passes against the Seattle Seahawks during the first quarter at Lumen Field. Mandatory Credit: Steven Bisig-Imagn Images

Even In Defeat, Colts' Philip Rivers Is Winning Over Doubters

Drake Wally

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Dec 16, 2025

Nov 30, 2025; Indianapolis, Indiana, USA; Indianapolis Colts head coach Shane Steichen during the first half against the Houston Texans at Lucas Oil Stadium.

The One 2026 Free Agent Colts Can't Afford to Lose

Sean Ackerman

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Dec 16, 2025

Patriots tight end Hunter Henry, left, and quarterback Drake Maye on the sideline at the end of their loss to the Bills.

NFL Power Rankings: Patriots Slip Out of Top Five After Loss to Bills

Conor Orr

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Dec 16, 2025

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts quarterback Philip Rivers (17) passes against the Seattle Seahawks during the fourth quarter at Lumen Field. Mandatory Credit: Steven Bisig-Imagn Images

3 Reasons Philip Rivers Gives Colts Best Playoff Hope

Drake Wally

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Dec 16, 2025

Matthew Stafford and the Rams are headed to Seattle on Thursday night.

NFL Week 16 Schedule 2025: Full List of Games, Times & TV Info

Mike Kadlick

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Dec 16, 2025

Philip Rivers walks to the locker room at halftime of the Colts’ 18–16 loss to the Seahawks.

Seahawks Kicker Explains Why He Felt Bad Beating Philip Rivers, Colts

Tom Dierberger

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Dec 15, 2025

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