How to watch Buccaneers vs 49ers: TV channel, livestream, kickoff time

Don't miss a second of the action! Here's everything you need to know to watch the Tampa Bay Buccaneers take on the San Francisco 49ers in a battle for the top seed in the NFC.

Nov 10, 2024; Tampa, Florida, USA; Tampa Bay Buccaneers quarterback Baker Mayfield (6) Mandatory Credit: Nathan Ray Seebeck-Imagn Images | Nathan Ray Seebeck-Imagn Images

The Tampa Bay Buccaneers return home to Raymond James Stadium after another thrilling, last-minute victory over the Seattle Seahawks to push them to 4-1, setting up a high-stakes battle with the San Francisco 49ers for the NFC's top spot early in the season following the New York Giants' upset over the Philadelphia Eagles on Thursday Night Football.

Fans can expect a hard-fought matchup between two teams dealing with a slew of injuries as the Bucs aim to carry their momentum into this crucial game.

Whether you're watching on TV, streaming from anywhere or tuning in on the radio, we've got you covered. From kickoff time and channel info to the best ways to follow every snap live, BucsGameday has all the details you need.

Tampa Bay Buccaneers vs San Francisco 49ers Game Details

• Matchup: Tampa Bay Buccaneers vs San Francisco 49ers
• Date: Sunday, October 12th
• Kickoff Time: 4:25 PM EST
• Location: Tampa, Florida | Raymond James Stadium

Sep 28, 2025; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) Mandatory Credit: Darren Yamashita-Imagn Images | Darren Yamashita-Imagn Images

What channel is Buccaneers vs 49ers on?

The Buccaneers-49ers game will air on CBS. Check your local listings for coverage.

How to stream Buccaneers vs 49ers live

Fans can stream the game live on:
• NFL+ (mobile only)
• FuboTV (free trial available)
• Sling TV, Hulu + Live TV, YouTube TV (subscription required)

READ MORE: Will Buccaneers WR Chris Godwin play against the 49ers?

Radio and live audio

• Buccaneers Radio Network (WXTB 97.9 FM in Tampa)
• 49ers Radio Network (KGO 810 AM & The Bone 107.7 FM in the Bay Area)
• SiriusXM NFL Radio (nationwide)

Sep 21, 2025; Tampa, Florida, USA; Tampa Bay Buccaneers safety Antoine Winfield Jr. (31) is congratulated by outside linebacker Lavonte David (54) Mandatory Credit: Kim Klement Neitzel-Imagn Images | Kim Klement Neitzel-Imagn Images

Buccaneers vs 49ers betting odds

Odds provided by DraftKings.

• Spread: Buccaneers -3
• Over/Under: 47.5
• Moneyline: Buccaneers -162, 49ers +136

Game odds refresh periodically and are subject to change.
If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

Buccaneers vs 49ers preview

The Tampa Bay Buccaneers return home for a high-stakes NFC showdown with the San Francisco 49ers, as both teams battle for the top spot in the conference early in the 2025 season. The Bucs will be without key contributors like Mike Evans, Bucky Irving, Jamel Dean and Benjamin Morrison, but Baker Mayfield is ready to go and rookie Emeka Egbuka continues to prove why the Bucs spent a first-round pick on him.

On defense, Tampa Bay's front seven, led by Vita Vea, Haason Reddick and Yaya Diaby, will test the 49ers' offensive line and quarterback Mac Jones, who will once again fill in for the injured Brock Purdy. Fans can expect a hard-hitting matchup that will challenge both teams' depth, resilience and early NFC playoff positioning. Key matchups, star performances and late-game execution will likely determine who takes control of the NFC race.

READ MORE: Buccaneers defensive position group banged up again ahead of 49ers game

Stick with BucsGameday for more coverage of the Tampa Bay Buccaneers throughout the 2025 season.

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