Bills vs. Saints expert picks: Is anyone predicting a New Orleans win over Buffalo?

We searched high and low for a brave soul who picked the New Orleans Saints to beat the Buffalo Bills on Sunday.

Buffalo Bills quarterback Josh Allen. | Chuck Cook-Imagn Images

The Week 4 game between the Buffalo Bills and New Orleans Saints features two teams going in completely opposite directions.

The Bills once again have their sights set on winning a Super Bowl in 2025 and are looking the part of an elite team following a 3-0 start to the season.

Meanwhile, the Saints are awful, as we all expected, and the team is in desperate need of a rebuild as it rides the fast track to a lost season.

As a result of their respective situations, the expectation is the Bills will go into Highmark Stadium on Sunday and crush the Saints.

Sep 18, 2025; Orchard Park, New York, USA; Buffalo Bills quarterback Josh Allen (17) carries the ball in the fourth quarter against the Miami Dolphins | Mark Konezny-Imagn Images

But that also sets this contest up to be the ultimate trap game for the Bills, something the NFL is infamous for.

RELATED: No change on Bills' latest Week 4 injury report with three starters still out

With the Bills such a heavy favorite, is there any expert out there who is brave enough to pick the Saints? Let's find out.

ESPN

• Stephania Bell: Bills

• Matt Bowen: Bills

• Mike Clay: Bills

• Jeremy Fowler: Bills

• Dan Graziano: Bills

• Kalyn Kahler: Bills

• Pamela Maldonado: Bills

• Eric Moody: Bills

• Jason Reid: Bills

• Lindsey Thiry: Bills

• Seth Wickersham: Bills

CBS Sports

• Pete Prisco: Bills

• Cody Benjamin: Bills

• Jared Dubin: Bills

• Ryan Wilson: Bills

• John Breech: Bills

• Tyler Sullivan: Bills

• Dave Richard: Bills

• Jamey Eisenberg: Bills

NFL.com

• Ali Bhanpuri: Bills (33-17)

• Tom Blair: Bills (31-14)

• Brooke Cersosimo: Bills (43-23)

• Gennaro Filice: Bills (32-17)

• Dan Parr: Bills (34-14)

Vinnie Iyer, The Sporting News

Iyer: "The Saints don't have much of a run defense or downfield passing game. That plays right into the hands of Josh Allen and James Cook as Buffalo rolls a non-conference foe at home." Pick — Bills 34, Saints 17

Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

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