Three-leg parlay returns 7x your money in Bills-Eagles Week 17 matchup

The Eagles' running back could have a big game on Sunday.

Dec 20, 2025; Landover, Maryland, USA; Philadelphia Eagles running back Saquon Barkley (26) celebrates after scoring a touchdown against the Washington Commanders in the second half at Northwest Stadium. | Geoff Burke-Imagn Images

It should be an exciting afternoon of football at Highmark Stadium, as the Buffalo Bills get set to host the reigning Super Bowl champion Philadelphia Eagles for a late-season non-conference matchup.

And while you’re enjoying some holiday competition, why not make some money in the process?

Here is a Bills-Eagles three-leg parlay that could help you earn some cash this weekend:

(All odds per FanDuel.)

RELATED: Three Bills' players could earn major six-figure paydays against Eagles in Week 17

Dec 14, 2025; Philadelphia, Pennsylvania, USA; Philadelphia Eagles running back Saquon Barkley (26) against the Las Vegas Raiders at Lincoln Financial Field. | Eric Hartline-Imagn Images

Saquon Barkley 100-plus yards rushing (+152)

Buffalo is allowing the fourth-most yards rushing per game (144.3) in the NFL this season, and this week it will face an Eagles ground game that has performed well over the past few weeks. Barkley has totaled 122 yards rushing or more in two of the last three weeks, including a 132-yard performance against the Washington Commanders in Week 16.

This should be a big day for the Philadelphia ball carrier.

MORE: Key matchup will decide fate of Bills' passing game vs. Eagles in Week 17

The defense line of the Bills line up near the end zone to try and stop Tampa Bay from scoring during second half action against the Tampa Bay Buccaneers on Nov 16, 2025 at Highmark Stadium in Orchard Park. | Tina MacIntyre-Yee/Democrat and Chronicle / USA TODAY NETWORK via Imagn Images

Saquon Barkley anytime TD (+105)

The Bills have allowed at least one rushing touchdown per game and seven total across their last four matchups, which creates a golden opportunity for Barkley to continue his recent scoring streak. He has found the end zone in each of the previous three weeks, which broke a four-game dry spell for the Eagles’ running back.

Additionally, Buffalo is without two contributing defensive tackles, with Jordan Phillips and DaQuan Jones both out due to injury. Riding Barkley is a smart play this week.

RELATED: Buffalo Bills will avoid two key Eagles players out with injuries in Week 17

Jan 26, 2025; Kansas City, MO, USA; Buffalo Bills defensive tackle DaQuan Jones (92) against the Kansas City Chiefs during the AFC Championship game at GEHA Field at Arrowhead Stadium. | Mark J. Rebilas-Imagn Images

Under 44.5 (-110)

Buffalo managed just 23 points against the Cleveland Browns this past week, which is more than five points fewer than its season average. And this week, the Bills will go up against an Eagles’ defense that has allowed just 14.8 points per contest since its Week 9 bye week.

Moreover, the weather is expected to be horrendous in Orchard Park on Sunday, with freezing rain forecast to fall throughout the game. That could affect how each offense operates in the passing game.

Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

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