Dallas Cowboys vs New York Giants odds for Week 2 of 2025 NFL season

The Dallas Cowboys host the NFC East rival New York Giants in Week 2 of the 2025 NFL regular season. Here is how the oddsmakers think the action will go down.

Dallas Cowboys quarterback Dak Prescott calls out the defense before the snap against the New York Giants at MetLife Stadium. | Julian Leshay Guadalupe/NorthJersey.com / USA TODAY NETWORK via Imagn Images

In a matter of hours, the Dallas Cowboys take the field at AT&T Stadium for a Week 2 showdown against the division rival New York Giants as the NFL regular season rolls on.

Both teams are aiming for their first win of the 2025 campaign, while the Cowboys are hoping to expend an impressive streak.

The Cowboys enter Sunday looking to extend a 14-season streak of avoiding a 0-2 start, which is the second-longest active streak in the league behind the Green Bay Packers (19). Dallas has also won 15 of the last 16 meetings between the two teams, including eight straight.

MORE: 3 key matchups that will decide Dallas Cowboys vs Giants showdown in Week 2

Will the streak continue on Sunday? The oddsmakers are on their side.

New York Giants wide receiver Malik Nabers and Dallas Cowboys cornerback Trevon Diggs wait for a review at MetLife Stadium. | Julian Leshay Guadalupe/NorthJersey.com / USA TODAY NETWORK via Imagn Images

Entering the afternoon kickoff, ESPN BET favors the Cowboys by five points over the visiting G-Men, while the over/under is set for 48.5 total points.

With the moneyline, the Cowboys are -240 favorites, and the Giants are +200 underdogs. That means a $100 bet on the Giants would land you a $200 return, but you would need to be willing to risk $240 to net $100 in profit.

Additional information on how to catch Sunday's game can be seen below.

Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

MORE: Cowboys vs Giants, NFL Week 2: Start time, live stream, TV channel

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New York Giants at Dallas Cowboys viewing info

Dallas Cowboys cheerleader performs during the game against the Atlanta Falcons at AT&T Stadium | Kevin Jairaj-Imagn Images

Date: Sunday, September 14, 2025
Start Time: 1:00 p.m. ET
Location: Arlington, Texas
Venue: AT&T Stadium
TV Channel: FOX

Betting Odds: Cowboys -5.5 | O/U: 48.5

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