Best Betting Picks and Predictions Today - Sports Illustrated | SI.com

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San Francisco 49ers quarterback Brock Purdy is a great prop target on Sunday.

San Francisco 49ers quarterback Brock Purdy is a great prop target on Sunday.

Breaking down the best picks and predictions for the San Francisco 49ers-Chicago Bears matchup on Sunday night.

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Bet on Philip Rivers to go over his passing yards total against the Jaguars.

Arizona Cardinals tight end Trey McBride is a great prop target on Sunday.

Bet on the Eagles to upset the Bills in NFL Week 17 action.

JC French IV and Georgia Southern are favored against Appalachian State on Monday.

San Francisco 49ers wide receiver Ricky Pearsall.

Chicago Bears wide receiver Rome Odunze.

San Francisco 49ers tight end George Kittle.

Chicago Bears wide receiver DJ Moore is a great prop target on Sunday.

Buffalo Bills tight end Dalton Kincaid.

New England Patriots running back Treveyon Henderson.

San Francisco 49ers running back Christian McCaffrey is a great prop target on Sunday night.

Arizona Cardinals wide receiver Marvin Harrison Jr.

New Orleans Saints wide receiver Chris Olave.

Chicago Bears quarterback Caleb Williams.

New Orleans Saints running back Alvin Kamara.

Browns tight end Harold Fannin Jr.

Bet on Saquon Barkley to go over his rushing yards total against the Bills in Week 17.

The Philadelphia Eagles and quarterback Jalen Hurts are underdogs in Week 17.

Seattle Seahawks wide receiver Jaxon Smith-Njigba is a great prop target on Sunday.

The Packers are home favorites against the Ravens in NFL Week 17 action.

The Philadelphia Eagles and running back Saquon Barkley are underdogs in Week 17.

Jayden Reed is a great bet to score against the Ravens on Saturday night.

The Green Bay Packers and running back Josh Jacobs are favored in Week 17.

Bet on Derrick Henry to go over his rushing yards total in Week 17 against the Packers.