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The Philadelphia Eagles and quarterback Jalen Hurts are underdogs in Week 17.

The Philadelphia Eagles and quarterback Jalen Hurts are underdogs in Week 17.

The SI Betting team breaks down their favorite bets for Week 17 of the 2025 NFL season, including a pick for the Philadelphia Eagles-Buffalo Bills matchup.

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Bet on Saquon Barkley to go over his rushing yards total against the Bills in Week 17.

Seattle Seahawks wide receiver Jaxon Smith-Njigba is a great prop target on Sunday.

The Packers are home favorites against the Ravens in NFL Week 17 action.

The Philadelphia Eagles and running back Saquon Barkley are underdogs in Week 17.

Jayden Reed is a great bet to score against the Ravens on Saturday night.

The Green Bay Packers and running back Josh Jacobs are favored in Week 17.

Bet on Derrick Henry to go over his rushing yards total in Week 17 against the Packers.

Houston Texans running back Woody Marks.

Green Bay Packers wide receiver Christian Watson.

Baltimore Ravens quarterback Lamar Jackson.

Green Bay Packers quarterback Jordan Love.

The Texans and Chargers are set to face off in Week 17 action.

Bet on Missouri to beat Virginia in the Gator Bowl on Saturday.

Conner Weigman and Houston are favored against LSU on Saturday.

The Los Angeles Chargers and quarterback Justin Herbert are favored in Week 17.

Bet on Jayden Higgins of the Texans to score a touchdown in Week 17 against the Chargers.

Bet the UNDER on Justin Herbert's passing yards total against the Texans in Week 17.

The Seattle Seahawks and quarterback Sam Darnold are favored in Week 17.

The Green Bay Packers and head coach Matt LaFleur clinched a playoff spot on Thursday.

The Denver Broncos and quarterback Bo Nix are favored to get the No. 1 seed in the AFC.

Portland Trail Blazers center Donovan Clingan is a solid prop target on Friday.

The Utah Jazz and forward Lauri Markkanen are home dogs on Friday night.

Philadelphia 76ers guard Tyrese Maxey is a great prop target on Friday.

Boston Celtics guard Jaylen Brown is a great prop target on Friday.