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Nov 30, 2025; Cleveland, Ohio, USA;  The San Francisco 49ers huddle up after the break during the second half against the Cleveland Browns at Huntington Bank Field. Mandatory Credit: Scott Galvin-Imagn Images

49ers Will be Without Two Skilled Starters Against Indianapolis

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43 Minutes Ago
Sep 14, 2025; Indianapolis, Indiana, USA; Indianapolis Colts defensive tackle DeForest Buckner (99) celebrates a tackle against Denver Broncos quarterback Bo Nix (10) during the fourth quarter at Lucas Oil Stadium. Mandatory Credit: Robert Goddin-Imagn Images

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Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers general manager John Lynch, right, talks with head coach Kyle Shanahan during pregame warmups against the Seattle Seahawks at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

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August 23, 2025; Santa Clara, California, USA; San Francisco 49ers defensive coordinator Robert Saleh before the game against the Los Angeles Chargers at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images

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Dec 14, 2025; Santa Clara, California, USA;  San Francisco 49ers quarterback Brock Purdy (13) runs with the ball during the first quarter against the Tennessee Titans at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

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Nov 30, 2025; Cleveland, Ohio, USA;  Cleveland Browns running back Dylan Sampson (22) runs the ball during the second half against the San Francisco 49ers at Huntington Bank Field. Mandatory Credit: Ken Blaze-Imagn Images

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Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers defensive coordinator Robert Saleh speaks with 49ers safety Malik Mustapha (6)  in the third quarter against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images

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Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers general manager John Lynch speaks on the sidelines before the game against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images

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Dec 19, 2025

Sep 29, 2024; Santa Clara, California, USA; San Francisco 49ers wide receiver Brandon Aiyuk (11) warms up before the game against the New England Patriots at Levi's Stadium. Mandatory Credit: Sergio Estrada-Imagn Images

This Is the Most Honest Take on the 49ers-Brandon Aiyuk Situation

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Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts quarterback Philip Rivers (17) walks to the huddle during the first quarter against the Seattle Seahawks at Lumen Field. Mandatory Credit: Kevin Ng-Imagn Images

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Dec 19, 2025

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Oct 2, 2025; Inglewood, California, USA; San Francisco 49ers head coach Kyle Shanahan during the second half at SoFi Stadium. Mandatory Credit: Kirby Lee-Imagn Images

Kyle Shanahan Sounds Off on the Colts’ Run Game

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Dec 14, 2025; New Orleans, Louisiana, USA; New Orleans Saints quarterback Tyler Shough (6) throws the ball during the second quarter against the Carolina Panthers at Caesars Superdome. Mandatory Credit: Matthew Hinton-Imagn Images

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Nov 24, 2025; Santa Clara, California, USA; San Francisco 49ers head coach Kyle Shanahan walk off the field after defeating the Carolina Panthers at Levi's Stadium. Mandatory Credit: Kelley L Cox-Imagn Images

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Dec 19, 2025

Jordan Love led the Packers to a 28–21 win over the Bears two weeks ago.

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Dec 19, 2025
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