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Nov 30, 2025; Cleveland, Ohio, USA; The San Francisco 49ers huddle up after the break during the second half against the Cleveland Browns at Huntington Bank Field. Mandatory Credit: Scott Galvin-Imagn Images

49ers Will be Without Two Skilled Starters Against Indianapolis

Jose Sanchez

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43 Minutes Ago

Sep 14, 2025; Indianapolis, Indiana, USA; Indianapolis Colts defensive tackle DeForest Buckner (99) celebrates a tackle against Denver Broncos quarterback Bo Nix (10) during the fourth quarter at Lucas Oil Stadium. Mandatory Credit: Robert Goddin-Imagn Images

49ers Make it Clear How They Feel About DeForest Buckner

Jose Sanchez

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48 Minutes Ago

Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers general manager John Lynch, right, talks with head coach Kyle Shanahan during pregame warmups against the Seattle Seahawks at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

49ers Put an End to This Rookie's Season

Jose Sanchez

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1 Hour Ago

August 23, 2025; Santa Clara, California, USA; San Francisco 49ers defensive coordinator Robert Saleh before the game against the Los Angeles Chargers at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images

Robert Saleh Gives Surprising Comments on the 49ers’ Run Defense

Jose Sanchez

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2 Hours Ago

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Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) runs with the ball during the first quarter against the Tennessee Titans at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

Brock Purdy Sounds Off on the Colts’ Defense

Jose Sanchez

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3 Hours Ago

Colts defensive tackle DeForest Buckner is set to return to the lineup on Monday night.

Colts Receive Good News on DT DeForest Buckner Ahead of Monday’s Game vs. Niners

Mike McDaniel

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4 Hours Ago

Eric Saubert

Seahawks Week 16 rooting guide: is clinching NFC No. 1 seed on the table?

Richie Whitt

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5 Hours Ago

Nov 30, 2025; Cleveland, Ohio, USA; Cleveland Browns running back Dylan Sampson (22) runs the ball during the second half against the San Francisco 49ers at Huntington Bank Field. Mandatory Credit: Ken Blaze-Imagn Images

What the Biggest Challenge Will be for the 49ers Against Indianapolis

Jose Sanchez

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5 Hours Ago

Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers defensive coordinator Robert Saleh speaks with 49ers safety Malik Mustapha (6) in the third quarter against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images

One 49ers Player is Garnering Heavy Praise From Robert Saleh

Jose Sanchez

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7 Hours Ago

Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers general manager John Lynch speaks on the sidelines before the game against the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images

John Lynch Dismisses “Injury-Prone” Label for This 49ers Player

Henry Cheal

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Dec 19, 2025

Sep 29, 2024; Santa Clara, California, USA; San Francisco 49ers wide receiver Brandon Aiyuk (11) warms up before the game against the New England Patriots at Levi's Stadium. Mandatory Credit: Sergio Estrada-Imagn Images

This Is the Most Honest Take on the 49ers-Brandon Aiyuk Situation

Henry Cheal

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Dec 19, 2025

5 49ers who need to step up to beat the Colts

Parker Hurley

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Dec 19, 2025

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts quarterback Philip Rivers (17) walks to the huddle during the first quarter against the Seattle Seahawks at Lumen Field. Mandatory Credit: Kevin Ng-Imagn Images

Colts' Limited Offense Reveals Clear Betting Value vs. 49ers

Michael Greene

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Dec 19, 2025

3 ways the San Francisco 49ers can expose the Indianapolis Colts

Parker Hurley

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Dec 19, 2025

Oct 2, 2025; Inglewood, California, USA; San Francisco 49ers head coach Kyle Shanahan during the second half at SoFi Stadium. Mandatory Credit: Kirby Lee-Imagn Images

Kyle Shanahan Sounds Off on the Colts’ Run Game

Jose Sanchez

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Dec 19, 2025

Dec 14, 2025; New Orleans, Louisiana, USA; New Orleans Saints quarterback Tyler Shough (6) throws the ball during the second quarter against the Carolina Panthers at Caesars Superdome. Mandatory Credit: Matthew Hinton-Imagn Images

NFL Week 16 Survival Pool Strategy: Saints, Texans and 3 More Winning Picks

Michael Rovetto

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Dec 19, 2025

4 Indianapolis Colts that the San Francisco 49ers must focus on

Parker Hurley

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Dec 19, 2025

Nov 24, 2025; Santa Clara, California, USA; San Francisco 49ers head coach Kyle Shanahan walk off the field after defeating the Carolina Panthers at Levi's Stadium. Mandatory Credit: Kelley L Cox-Imagn Images

One 49ers player is almost guaranteed to get a $500k bonus vs. Colts

Henry Cheal

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Dec 19, 2025

Jordan Love led the Packers to a 28–21 win over the Bears two weeks ago.

Key Matchups, Predictions for Packers-Bears and More NFL Week 16 Games

Matt Verderame

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Dec 19, 2025

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