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Philip Rivers will make his second start of the season against the 49ers.

49ers vs. Colts Prediction, Odds, Spread, Injuries, Trends for NFL Week 16

Iain MacMillan

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Dec 17, 2025

The ideal playoff seed for the 49ers' Super Bowl hopes

Parker Hurley

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Dec 17, 2025

Seattle Seahawks wide receiver Jaxon Smith-Njigba is the favorite to win the OPOY award.

NFL Offensive Player of the Year Odds: Jaxon Smith-Njigba Set as Major Favorite Ahead of Week 16

Peter Dewey

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Dec 17, 2025

Tom Brady, Adrian Peterson, and Joe Burrow havev all gone onto have success post-ACL tear.

How NFL Stars Have Performed Post-ACL Tear in Wake of Mahomes, Parsons Injuries

Mike Kadlick

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Dec 17, 2025

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Alabama quarterback Ty Simpson could be the pick for the Steelers in the first round of the 2026 NFL draft.

2026 NFL Mock Draft 4.0: Steelers Select Aaron Rodgers’s Replacement

Daniel Flick

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Dec 17, 2025

Kyle Shanahan shares the times they call Brock Purdy Michael Jordan.

Kyle Shanahan Shares Funny Reason for Calling Brock Purdy ‘Michael Jordan’

Eva Geitheim

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Dec 16, 2025

The 49ers don't seem thrilled to face Philip Rivers

Grant Cohn

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Dec 16, 2025

Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers wide receiver Ricky Pearsall (1) stiff arms Tennessee Titans cornerback Marcus Harris (26) during the third quarter at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

What 49ers' Ricky Pearsall's Latest Injury Says About Him

Jose Sanchez

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Dec 16, 2025

August 23, 2025; Santa Clara, California, USA; San Francisco 49ers defensive coordinator Robert Saleh before the game against the Los Angeles Chargers at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images

How the 49ers Can Fix their Defense

Tom Jensen

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Dec 16, 2025

Nov 16, 2025; Madrid, Spain; Miami Dolphins place kicker Riley Patterson (47) kicks a field goal against the Washington Commanders in overtime during the 2025 NFL Madrid Game at Santiago Bernabeu Stadium. Mandatory Credit: Kirby Lee-Imagn Images

Riley Patterson and 2 Other Must-Start Kickers in Week 16 Fantasy Football

Thomas Carelli

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Dec 16, 2025

This 49ers player needs to step up to change the defense

Parker Hurley

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Dec 16, 2025

Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers wide receiver Ricky Pearsall (1) runs with the ball during the third quarter against Tennessee Titans cornerback Marcus Harris (26) and linebacker Cody Barton (50) at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

49ers Have Easy Decision to Make on Ricky Pearsall Against the Colts

Jose Sanchez

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Dec 16, 2025

The 49ers offense is peaking while the defense fades

Parker Hurley

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Dec 16, 2025

The Broncos are already in the playoffs, but can clinch the AFC West title and the AFC's No. 1 seed in Week 16.

Every AFC and NFC Playoff Clinching Scenario Heading into Week 16

Brigid Kennedy

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Dec 16, 2025

Nov 2, 2025; East Rutherford, New Jersey, USA; San Francisco 49ers head coach Kyle Shanahan on the sideline during the first half of a game against the New York Giants at MetLife Stadium. Mandatory Credit: Robert Deutsch-Imagn Images

Kyle Shanahan Shares What This 49ers Rookie Must Do to Play

Jose Sanchez

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Dec 16, 2025

Oct 19, 2025; Santa Clara, California, USA; San Francisco 49ers kicker Eddie Pineiro (18) after the game against the Atlanta Falcons at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images

Eddy Pineiro and Charlie Smyth Top Week 16 Waiver Wire Kicker Pickups

Chris Wassel

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Dec 16, 2025

Patriots tight end Hunter Henry, left, and quarterback Drake Maye on the sideline at the end of their loss to the Bills.

NFL Power Rankings: Patriots Slip Out of Top Five After Loss to Bills

Conor Orr

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Dec 16, 2025

The San Francisco 49ers and quarterback Brock Purdy are favored on Monday night.

NFL Week 16 Survivor Pool Picks (49ers, NFC South Squad Highlight Top Predictions)

Peter Dewey, Iain MacMillan

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Dec 16, 2025

Matthew Stafford and the Rams are headed to Seattle on Thursday night.

NFL Week 16 Schedule 2025: Full List of Games, Times & TV Info

Mike Kadlick

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Dec 16, 2025

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